In Silico Analysis of Potential Outer Membrane Beta-Barrel Proteins in Aeromonas hydrophila Pangenome
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DOI: 10.1007/s10989-021-10259-z
Abstract: Outer membrane proteins (OMPs) of Aeromonas hydrophila have a variety of functional roles in virulence and pathogenesis and represent promising targets for vaccine development. The main objective of this study was to develop an in-silico… read more here.
Keywords: barrel; hydrophila; outer membrane; beta barrel ... See more keywords
Improving 3D Structure Prediction of Beta-Barrel Membrane Proteins
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DOI: 10.1016/j.bpj.2016.11.333
Abstract: Beta-barrel membrane proteins are found in the outer membrane of gram-negative bacteria, mitochondria, and chloroplasts. They carry out diverse biological functions, including pore formation, membrane anchoring, enzyme activity, and bacterial virulence. In addition, beta-barrel membrane… read more here.
Keywords: barrel; barrel membrane; beta barrel; structure ... See more keywords
De novo design of small beta barrel proteins
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DOI: 10.1073/pnas.2207974120
Abstract: Significance De novo design of mini-proteins for engineering new functions has primarily focused on all-alpha and alpha-beta folds. Despite the enormous functional diversity observed in naturally occurring beta barrels less than 70 residues in length,… read more here.
Keywords: small beta; beta barrel; novo design; design small ... See more keywords
Efficient computation of transfer free energies of amino acids in beta‐barrel membrane proteins
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DOI: 10.1093/bioinformatics/btx053
Abstract: Motivation: Transmembrane beta‐barrel proteins (TMBs) serve a multitude of essential cellular functions in Gram‐negative bacteria, mitochondria and chloroplasts. Transfer free energies (TFEs) of residues in the transmembrane (TM) region provides fundamental quantifications of thermodynamic stabilities… read more here.
Keywords: free energies; membrane; beta barrel; transfer free ... See more keywords
The Functional Significance of Hydrophobic Residue Distribution in Bacterial Beta-Barrel Transmembrane Proteins
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DOI: 10.3390/membranes11080580
Abstract: β-barrel membrane proteins have several important biological functions, including transporting water and solutes across the membrane. They are active in the highly hydrophobic environment of the lipid membrane, as opposed to soluble proteins, which function… read more here.
Keywords: beta barrel; membrane proteins; transmembrane proteins; barrel ... See more keywords