High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta‐catenin from Forkhead box O to T cell factor interaction
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2085
Abstract: Diabetes, which is characterized by an increase in blood glucose concentration, is accompanied by low bone turnover, increased fracture risk, and the formation of embryonic skeletal malformations. Yet, there are few studies elucidating the underlying… read more here.
Keywords: beta catenin; high glucose; osteogenic differentiation;
WDR34 Activates Wnt/Beta-Catenin Signaling in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05583-w
Abstract: BackgroundWnt ligand binding initiates the interaction between Frizzled and Dvl proteins. However, the regulation of Frizzled–Dvl proteins interaction remains largely unknown.AimsThe present study aims to elucidate the regulation of Frizzled–Dvl interaction by WDR34.MethodsThe protein levels… read more here.
Keywords: wdr34; hepatocellular carcinoma; hcc; beta catenin ... See more keywords
Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0947-4
Abstract: Exudative age-related macular degeneration (AMD) is characterized by molecular mechanisms responsible for the initiation of choroidal neovascularization (CNV). Inflammatory processes are associated with upregulation of the canonical WNT/beta-catenin pathway in exudative AMD. We focus this… read more here.
Keywords: beta catenin; wnt beta; catenin pathway; aerobic glycolysis ... See more keywords
Desmoplastic fibroma of the jaw bones: A series of twenty-two cases
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone Oncology"
DOI: 10.1016/j.jbo.2020.100333
Abstract: Highlights • In desmoid-type soft tissue fibromatosis we could see the beta-catenin in the nuclei of neoplastic cells as a diagnostic feature.• Beta-catenin in the nuclei of neoplastic cells could not be detected in the… read more here.
Keywords: beta catenin; fibroma jaw; desmoplastic fibroma; bone ... See more keywords
Immunoexpression of Heat Shock Protein 70, Glypican 3, Glutamine Synthetase, and Beta-Catenin in Hepatocellular Carcinoma After Liver Transplantation: Association Between Positive Glypican 3 and Beta-Catenin With the Presence of Larger Nodules.
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2017.01.048
Abstract: BACKGROUND Hepatocellular carcinoma (HCC) is the 6th leading cause of cancer worldwide. Its recurrence ranges from 6% to 26%. In the literature, many factors are associated with higher risk of recurrence, without a clear definition… read more here.
Keywords: beta catenin; association; liver transplantation; beta ... See more keywords
CDK7 activated beta‐catenin/TCF signaling in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.07.010
Abstract: &NA; Over‐activation of beta‐catenin/TCF signaling is very common in the progression of hepatocellular carcinoma (HCC). The molecular mechanisms leading to the aberrant activation of beta‐catenin/TCF signaling are not fully understood. In this study, it was… read more here.
Keywords: beta catenin; tcf signaling; catenin tcf; beta ... See more keywords
Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions.
Sign Up to like & getrecommendations! Published in 2017 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2017.01.016
Abstract: Conjunctival melanocytic lesions encompass a group of clinically diverse, benign to malignant, neoplasms that may contain overlapping histopathological features, making definitive diagnosis challenging in some cases. In this series, we compared multiple immunohistochemical (IHC) markers… read more here.
Keywords: beta catenin; melanocytic lesions; conjunctival; conjunctival melanocytic ... See more keywords
Targeting Wnt/beta-catenin signaling in CTNNB1-mutant endometrial cancer
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)00722-8
Abstract: Objectives: CTNNB1 (gene encoding for beta-catenin) mutations convey increased rates of recurrence in early stage, low grade endometrial cancer (EC). The role of beta-catenin/TCF transcriptional activity in EC recurrence is not well understood. We aim… read more here.
Keywords: beta catenin; ctnnb1 mutant; cell; beta ... See more keywords
LncRNA PVT1 regulates triple-negative breast cancer through KLF5/beta-catenin signaling
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DOI: 10.1038/s41388-018-0310-4
Abstract: AbstactRecent molecularly targeted approach gains advance in breast cancer treatment. However, the estimated 5-year survival rate has not met the desired expectation for improvement, especially for patients with triple-negative breast cancer (TNBC). Here we report… read more here.
Keywords: beta catenin; pvt1; catenin; breast cancer ... See more keywords
ALG8 Fuels Stemness Through Glycosylation of the WNT/Beta-Catenin Signaling Pathway in Colon Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2022.0165
Abstract: Cancer stem cells (CSCs) drive tumor relapse, which is a major clinical challenge in colon cancer. Targeting CSCs presents a great opportunity in eradicating cancer cells and thus treatment of patients with cancer. However, the… read more here.
Keywords: beta catenin; wnt beta; alg8 gene; colon cancer ... See more keywords
A Comparative Analysis of Immunohistochemical Profile of Primary and Metastatic Endometrial Endometrioid Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqaa161.066
Abstract: Beta catenin plays an important role in cancer tumorigenesis and have been found to be associated with metastasis in a variety of tumors. Analyzing TCGA data, we found that 30% of endometrial endometrioid carcinoma cases… read more here.
Keywords: carcinoma; endometrioid carcinoma; beta catenin; primary metastatic ... See more keywords