Beta‐Cell Tipe1 Orchestrates Insulin Secretion and Cell Proliferation by Promoting Gαs/cAMP Signaling via USP5
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DOI: 10.1002/advs.202304940
Abstract: Inadequate β‐cell mass and insulin secretion are essential for the development of type 2 diabetes (T2D). TNF‐α‐induced protein 8‐like 1 (Tipe1) plays a crucial role in multiple diseases, however, a specific role in T2D pathogenesis… read more here.
Keywords: insulin secretion; tipe1; cell; beta cell ... See more keywords
Associations of complete blood count parameters with pancreatic beta‐cell function and insulin resistance in prediabetes and type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24454
Abstract: Previous studies found controversial associations of CBC parameters with pancreatic beta‐cell function (BCF) and insulin resistance (IR). The aim of this was to determine the independent associations of CBC parameters with BCF and IR in… read more here.
Keywords: parameters pancreatic; prediabetes type; insulin resistance; cell function ... See more keywords
Rat Pancreatic Beta-Cell Culture.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7571-6_20
Abstract: In this chapter, we describe the methods used to culture mainly rat pancreatic beta cells. We consider necessary to use this approach to get more information about physiological, biophysical, and molecular biology characteristics of primary… read more here.
Keywords: beta cells; beta; biology; beta cell ... See more keywords
The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03499-7
Abstract: Unveiling the key pathways underlying postnatal beta-cell proliferation can be instrumental to decipher the mechanisms of beta-cell mass plasticity to increased physiological demand of insulin during weight gain and pregnancy. Using transcriptome and global Serine… read more here.
Keywords: beta; dlk jnk3; beta cell;
Translation of curative therapy concepts with T cell and cytokine antibody combinations for type 1 diabetes reversal in the IDDM rat
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-020-01941-8
Abstract: Proinflammatory cytokines released from the pancreatic islet immune cell infiltrate in type 1 diabetes (T1D) cause insulinopenia as a result of severe beta cell loss due to apoptosis. Diabetes prevention strategies targeting different cytokines with… read more here.
Keywords: combination; beta cell; anti tnf; anti tcr ... See more keywords
Effects of semaglutide on beta cell function and glycaemic control in participants with type 2 diabetes: a randomised, double-blind, placebo-controlled trial
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4289-0
Abstract: Aims/hypothesisSemaglutide is a glucagon-like peptide-1 analogue in development for the treatment of type 2 diabetes. Its effects on first- and second-phase insulin secretion and other measures of beta cell function and glycaemic control were assessed.MethodsIn… read more here.
Keywords: function glycaemic; treatment; cell function; glycaemic control ... See more keywords
Relapsing/remitting type 1 diabetes
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DOI: 10.1007/s00125-017-4403-3
Abstract: Aims/hypothesisType 1 diabetes is believed to be an autoimmune disease associated with irreversible loss of insulin secretory function that follows a chronic progressive course. However, it has been speculated that relapsing/remitting disease progression may occur… read more here.
Keywords: function; type diabetes; relapsing remitting; beta cell ... See more keywords
Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4559-5
Abstract: Aims/hypothesisImproved biomarkers are acutely needed for the detection of developing type 1 diabetes, prior to critical loss of beta cell mass. We previously demonstrated that elevated beta cell microRNA 21-5p (miR-21-5p) in rodent and human… read more here.
Keywords: mir; type diabetes; cell; beta cell ... See more keywords
Activation of GLP-1 receptor signalling alleviates cellular stresses and improves beta cell function in a mouse model of Wolfram syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4679-y
Abstract: Aims/hypothesisLoss of functional beta cells results in a gradual progression of insulin insufficiency in Wolfram syndrome caused by recessive WFS1 mutations. However, beta cell dysfunction in Wolfram syndrome has yet to be fully characterised, and… read more here.
Keywords: insulin; beta; wolfram syndrome; beta cell ... See more keywords
Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass
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DOI: 10.1007/s00125-018-4743-7
Abstract: Aims/hypothesisPancreatic beta cells secrete insulin to maintain glucose homeostasis, and beta cell failure is a hallmark of type 2 diabetes. Glucose triggers insulin secretion in beta cells via oxidative mitochondrial pathways. However, it also feeds… read more here.
Keywords: insulin secretion; beta cell; mice; beta ... See more keywords
Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-05029-y
Abstract: Aims/hypothesis Progressive decline in functional beta cell mass is central to the development of type 2 diabetes. Elevated serum levels of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) are associated with beta cell failure in type 2 diabetes… read more here.
Keywords: enampt; type diabetes; cell; beta cell ... See more keywords