Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta‐TC‐6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23099
Abstract: Τhe natural history of type 2 diabetes mellitus is characterized by a progressive loss of pancreatic beta cell function and insulin resistance. Bisphenol A (BPA) is an endocrine‐disrupting chemical that is used widely in industry;… read more here.
Keywords: reactive oxygen; species mitochondrial; beta; oxygen species ... See more keywords
Enhanced structure and function of human pluripotent stem cell‐derived beta‐cells cultured on extracellular matrix
Sign Up to like & getrecommendations! Published in 2020 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.20-0224
Abstract: The differentiation of human stem cells into insulin secreting beta‐like cells holds great promise to treat diabetes. Current protocols drive stem cells through stages of directed differentiation and maturation and produce cells that secrete insulin… read more here.
Keywords: stem; basement membrane; cell; beta cells ... See more keywords
Rat Pancreatic Beta-Cell Culture.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7571-6_20
Abstract: In this chapter, we describe the methods used to culture mainly rat pancreatic beta cells. We consider necessary to use this approach to get more information about physiological, biophysical, and molecular biology characteristics of primary… read more here.
Keywords: beta cells; beta; biology; beta cell ... See more keywords
Stimulus-Secretion Coupling in Beta-Cells: From Basic to Bedside.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_37
Abstract: Insulin secretion in humans is usually induced by mixed meals, which upon ingestion, increase the plasma concentration of glucose, fatty acids, amino acids, and incretins like glucagon-like peptide 1. Beta-cells can stay in the off-mode,… read more here.
Keywords: beta cells; secretion; secretion coupling; calcium ... See more keywords
Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4704-1
Abstract: Aims/hypothesisThe Coxsackie and adenovirus receptor (CAR) is a transmembrane cell-adhesion protein that serves as an entry receptor for enteroviruses and may be essential for their ability to infect cells. Since enteroviral infection of beta cells… read more here.
Keywords: beta cells; isoform; car siv; car ... See more keywords
Metabolic and functional specialisations of the pancreatic beta cell: gene disallowance, mitochondrial metabolism and intercellular connectivity
Sign Up to like & getrecommendations! Published in 2020 at "Diabetologia"
DOI: 10.1007/s00125-020-05205-5
Abstract: All forms of diabetes mellitus involve the loss or dysfunction of pancreatic beta cells, with the former predominating in type 1 diabetes and the latter in type 2 diabetes. Deeper understanding of the coupling mechanisms… read more here.
Keywords: beta cells; metabolism; beta; pancreatic beta ... See more keywords
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Sign Up to like & getrecommendations! Published in 2024 at "Diabetologia"
DOI: 10.1007/s00125-024-06123-6
Abstract: Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make distinct contributions to the overall control of insulin secretion. These include a subpopulation of highly connected ‘hub’ cells, important… read more here.
Keywords: cpg methylation; beta; cell; beta cell ... See more keywords
Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes
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DOI: 10.1007/s00125-024-06180-x
Abstract: Almost all beta cells contact one capillary and insulin granule fusion is targeted to this region. However, there are reports of beta cells contacting more than one capillary. We therefore set out to determine the… read more here.
Keywords: cell; contact; capillary contact; beta cells ... See more keywords
Molecular study of the proliferation process of beta cells derived from pluripotent stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06892-y
Abstract: BACKGROUND Diabetes mellitus (DM) is a chronic metabolic disorder, increasing in the number of patients and poses a severe threat to human health. Significant advances have been made in DM treatment; the most important of… read more here.
Keywords: beta cells; cells derived; beta; proliferation ... See more keywords
Increasing levels of insulin secretion in bioartificial pancreas technology: co-encapsulation of beta cells and nanoparticles containing GLP-1 in alginate hydrogels
Sign Up to like & getrecommendations! Published in 2020 at "Health and Technology"
DOI: 10.1007/s12553-020-00427-4
Abstract: The success of diabetes treatment with bioartificial pancreas is still hindered by a high rate of graft failure caused by poorly functioning cells. The incretin effect of glucagon like peptide-1 (GLP-1) make this peptide an… read more here.
Keywords: insulin; beta cells; nanoparticles containing; containing glp ... See more keywords
Aquaporin-7 and aquaporin-12 modulate the inflammatory phenotype of endocrine pancreatic beta-cells.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108481
Abstract: Aquaporins (AQPs) facilitate water and glycerol movement across membranes. AQP7 is the main aquaglyceroporin in pancreatic β-cells and was proposed to play a role in insulin exocytosis. Although AQP7-null mice display adult-onset obesity, impaired insulin… read more here.
Keywords: insulin; beta cells; insulin secretion; inflammation ... See more keywords