Variation in Target Attainment of Beta‐Lactam Antibiotic Dosing Between International Pediatric Formularies
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2180
Abstract: As antimicrobial susceptibility of common bacterial pathogens decreases, ensuring optimal dosing may preserve the use of older antibiotics in order to limit the spread of resistance to newer agents. Beta‐lactams represent the most widely prescribed… read more here.
Keywords: variation target; target attainment; attainment beta; beta lactam ... See more keywords
A non-beta-lactam antibiotic inhibitor for enterohemorrhagic Escherichia coli O104:H4
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01803-y
Abstract: The overuse of antibiotics has caused an increased prevalence of drug-resistant bacteria. Bacterial resistance in E. coli is regulated via production of β-lactam-hydrolyzing β-lactamases enzymes. Escherichia coli O104: H4 is a multi-drug resistant strain known… read more here.
Keywords: escherichia coli; non; coli o104; lactam ... See more keywords
Moving Past the Routine Use of Macrolides—Reviewing the Role of Combination Therapy in Community-Acquired Pneumonia
Sign Up to like & getrecommendations! Published in 2018 at "Current Infectious Disease Reports"
DOI: 10.1007/s11908-018-0651-8
Abstract: Purpose of ReviewDespite advances in diagnostic microbiology and sepsis management, community-acquired pneumonia (CAP) remains a significant cause of morbidity and mortality. Current recommendations regarding the use of beta-lactams in combination with macrolides published in clinical… read more here.
Keywords: combination; combination therapy; beta lactam;
Incidence and Predictive Factors Associated with Beta-Lactam Neurotoxicity in the Critically Ill: A Retrospective Cohort Study
Sign Up to like & getrecommendations! Published in 2022 at "Neurocritical Care"
DOI: 10.1007/s12028-022-01442-1
Abstract: Beta-lactam neurotoxicity is a relatively uncommon yet clinically significant adverse effect in critically ill patients. This study sought to define the incidence of neurotoxicity, derive a prediction model for beta-lactam neurotoxicity, and then validate the… read more here.
Keywords: lactam neurotoxicity; critically ill; neurotoxicity; cohort ... See more keywords
Efficacy of non‐beta lactam antibiotics for prevention of cesarean delivery wound infections: 14
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Obstetrics and Gynecology"
DOI: 10.1016/j.ajog.2017.08.094
Abstract: expression of CCL3 (a Th1 chemoattractant) and higher expression of CCL2 (a Th2 chemoattractant) at 1 and 2 wpi. In vitro, cervical epithelial cells infected with Ct expressed IL-1b when treated with vehicle control. P4… read more here.
Keywords: antibiotics prevention; lactam antibiotics; non beta; efficacy non ... See more keywords
Beta-lactam resistance development during the treatment processes of municipal wastewater treatment plants.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.130749
Abstract: This work monitored the effect of a municipal and a village wastewater treatment plant (WWTP) technology on the fate of beta-lactam resistance genes in bacterial populations in different phases of the wastewater treatment process. In… read more here.
Keywords: lactam resistance; treatment; resistance; wastewater treatment ... See more keywords
Impact of Beta-Lactam Allergy on Treatment of Outpatient Infections.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2019.10.001
Abstract: PURPOSE The most commonly reported medication allergies in the United States involve beta-lactam antibiotics, creating an important consideration for prescribers when choosing optimal treatment of infections. Currently, few data exist on outpatient prescribing patterns in… read more here.
Keywords: treatment; lactam; lactam allergy; beta lactam ... See more keywords
Towards a minimally invasive device for beta-lactam monitoring in humans.
Sign Up to like & getrecommendations! Published in 2017 at "Electrochemistry communications"
DOI: 10.1016/j.elecom.2017.07.011
Abstract: Antimicrobial resistance is a leading patient safety issue. There is a need to develop novel mechanisms for monitoring and subsequently improving the precision of how we use antibiotics. A surface modified microneedle array was developed… read more here.
Keywords: towards minimally; minimally invasive; beta; invasive device ... See more keywords
Beta-lactam-Induced Outer Membrane Alteration Confers E. coli a Fortuitous Competitive Advantage through Cross-Resistance to Bacteriophages
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Technology Letters"
DOI: 10.1021/acs.estlett.0c00318
Abstract: Bacteriophages play an important role in controlling bacteria populations; yet, little is known about their differential effects on antibiotic resistant bacteria (ARB) proliferation. Here, we repor... read more here.
Keywords: alteration confers; outer membrane; induced outer; membrane alteration ... See more keywords
Production of Natural Penicillin-Binding Protein 2 and Development of a Signal-Amplified Fluorescence Polarization Assay for the Determination of 28 Beta-Lactam Antibiotics in Milk.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c07028
Abstract: In this study, two magnetic activity-based protein profiling probes based on cephradine and amoxicillin were first synthesized that were used to produce the natural penicillin-binding protein 2 of Escherichia coli. After characterization by using LC-ESI-MS/MS,… read more here.
Keywords: natural penicillin; protein; beta lactam; lactam antibiotics ... See more keywords
Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38984-y
Abstract: In persons with cystic fibrosis (CF), decreased airway microbial diversity is associated with lower lung function. Conflicting data exist on the impact of short-term antibiotics for treatment of acute pulmonary exacerbations. However, whether differences in… read more here.
Keywords: lactam antibiotic; antibiotic exposure; diversity; beta lactam ... See more keywords