Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1868-1
Abstract: The gradual deterioration of cognitive functions in Alzheimer’s disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate that toxic oligomers of amyloid-beta may cause propagation of pathology in… read more here.
Keywords: alzheimer disease; amyloid beta; beta oligomers; pathology ... See more keywords
Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers
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DOI: 10.1038/s41598-020-63255-6
Abstract: Synapse loss occurs early and correlates with cognitive decline in Alzheimer’s disease (AD). Synaptotoxicity is driven, at least in part, by amyloid-beta oligomers (Aβo), but the exact synaptic components targeted by Aβo remain to be… read more here.
Keywords: alzheimer disease; amyloid beta; neuroligin altered; beta oligomers ... See more keywords
Amyloid Beta oligomers prevents Lysosomal targeting of miRNP to stop its recycling and target repression in glial cells.
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DOI: 10.1242/jcs.258360
Abstract: On exposure to Amyloid Beta Oligomers (Aβ1-42), glial cells start expressing proinflammatory cytokines although there has been increase in repressive miRNAs levels as well. Exploring the mechanism of this potential immunity of target cytokine mRNAs… read more here.
Keywords: beta oligomers; glial cells; lysosomal targeting; amyloid beta ... See more keywords
A hydrogel biosensor for high selective and sensitive detection of amyloid-beta oligomers
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s152163
Abstract: Background Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive and memory impairment. It is the most common neurological disease that causes dementia. Soluble amyloid-beta oligomers (AβO) in blood or cerebrospinal fluid (CSF)… read more here.
Keywords: detection; beta oligomers; biosensor; amyloid beta ... See more keywords