Electrochemical oxidation of amyloid-beta peptide isoforms on carbon screen printed electrodes
Sign Up to like & getrecommendations! Published in 2017 at "Electrochemistry Communications"
DOI: 10.1016/j.elecom.2016.12.009
Abstract: Abstract The direct electrochemical oxidation of synthetic analogs of the 42 amino acid long amyloid-beta peptide (Aβ42) and its isoforms with familial mutations (D7H or H6R) and the naturally occurring modification (Ser-8 phosphorylation) has been… read more here.
Keywords: oxidation; electrochemical oxidation; carbon screen; amyloid beta ... See more keywords
Amyloid-Beta (1-40) Peptide and Subclinical Cardiovascular Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.06.027
Abstract: Amyloid-beta (1-40) (Aβ40), a peptide with proinflammatory and proatherosclerotic properties, is associated with arterial aging [(1)][1] and with major adverse cardiovascular events in patients with stable coronary heart disease, heart failure, or acute coronary syndrome… read more here.
Keywords: amyloid beta; disease; subclinical cardiovascular; beta peptide ... See more keywords
A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc04660c
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc04660c
Abstract: An Fe corrole is shown to bind to the amyloid-beta peptide and limit reactive oxygen species generation and peptide aggregation of relevance to Alzheimer's disease. read more here.
Keywords: reactive oxygen; oxygen species; amyloid beta; peptide aggregation ... See more keywords
Amyloid-beta peptide and phosphorylated tau in the frontopolar cerebral cortex and in the cerebellum of toothed whales: aging vs hypoxia.
Sign Up to like & getrecommendations! Published in 2020 at "Biology open"
DOI: 10.1242/bio.054734
Abstract: Hypoxia could be a possible risk factor for neurodegenerative alterations in cetaceans' brain. Among toothed whales, the beaked whales are particularly cryptic and routinely dive deeper than 1,000 m for about one hour in order… read more here.
Keywords: cortex; toothed whales; amyloid beta; peptide phosphorylated ... See more keywords
Inhibiting amyloid beta (1–42) peptide-induced mitochondrial dysfunction prevents the degradation of synaptic proteins in the entorhinal cortex
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.960314
Abstract: Increasing evidence suggests that mitochondrial dysfunction and aberrant release of mitochondrial reactive oxygen species (ROS) play crucial roles in early synaptic perturbations and neuropathology that drive memory deficits in Alzheimer’s disease (AD). We recently showed… read more here.
Keywords: amyloid beta; entorhinal cortex; synaptic proteins; mitochondrial dysfunction ... See more keywords