LAUSR

Interactions between the Intrinsically Disordered Proteins β‐Synuclein and α‐Synuclein

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1 Published in 2018 at "PROTEOMICS"

DOI: 10.1002/pmic.201800109

Abstract: Several intrinsically disordered proteins have been implicated in the process of amyloid fibril formation in neurodegenerative disease, and developing approaches to inhibit the aggregation of these intrinsically disordered proteins is critical for establishing effective therapies… read more here.

Keywords: beta synuclein; synuclein; alpha synuclein; disordered proteins ... See more keywords

Targeted Mass Spectrometry Suggests Beta-Synuclein as Synaptic Blood Marker in Alzheimer's Disease.

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0 Published in 2020 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.9b00824

Abstract: Synaptic degeneration is a major hallmark of Alzheimer's disease (AD) and the best pathological correlate of cognitive dysfunction. Synaptic markers are therefore a highly desired read-out for patient diagnosis and possible follow-up in clinical trials.… read more here.

Keywords: beta synuclein; mass spectrometry; blood marker; alzheimer disease ... See more keywords

Alternative Splicing of Alpha- and Beta-Synuclein Genes Plays Differential Roles in Synucleinopathies

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0 Published in 2018 at "Genes"

DOI: 10.3390/genes9020063

Abstract: The synuclein family is composed of three members, two of which, α- and β-synuclein, play a major role in the development of synucleinopathies, including Parkinson’s disease (PD) as most important movement disorder, dementia with Lewy… read more here.

Keywords: beta synuclein; synuclein; synuclein genes; splicing alpha ... See more keywords

Neurochemical Monitoring of Traumatic Brain Injury by the Combined Analysis of Plasma Beta-Synuclein, NfL, and GFAP in Polytraumatized Patients

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1 Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23179639

Abstract: Traumatic brain injury (TBI) represents a major determining factor of outcome in severely injured patients. However, reliable brain-damage-monitoring markers are still missing. We therefore assessed brain-specific beta-synuclein as a novel blood biomarker of synaptic damage… read more here.

Keywords: injury; brain; gfap; beta synuclein ... See more keywords

Value of plasma alpha- and beta-synuclein levels in the diagnosis, severity, and functional outcome of acute ischemic stroke

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0 Published in 2024 at "Turkish Journal of Emergency Medicine"

DOI: 10.4103/tjem.tjem_17_24

Abstract: OBJECTIVE: We aimed to determine the role of plasma alpha- and beta-synuclein levels and other routine inflammatory parameters in the diagnosis, outcome, and mortality of acute ischemic stroke (AIS). METHODS: In our study, serum alpha-… read more here.

Keywords: synuclein levels; alpha beta; beta synuclein; plasma ... See more keywords