Betahistine prevents development of endolymphatic hydrops in a mouse model of insulin resistance and diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Acta Oto-Laryngologica"
DOI: 10.1080/00016489.2023.2171116
Abstract: Abstract Background Diabetes is associated with inner ear dysfunction. Furthermore, C57BL/6J mice fed high fat diet (HFD), a model for insulin resistance and diabetes, develop endolymphatic hydrops (EH). Aim Evaluate if betahistine, spironolactone (aldosterone antagonist)… read more here.
Keywords: insulin resistance; betahistine; resistance diabetes; model insulin ... See more keywords
A novel thermostable alkaline histamine oxidase from Glutamicibacter sp. N1A3101, induced by histamine and its analogue betahistine
Sign Up to like & getrecommendations! Published in 2020 at "AMB Express"
DOI: 10.1186/s13568-020-01115-2
Abstract: Biogenic amines (BAs) are low molecular weight organic bases formed by natural amino acids decarboxylation and trigger an array of toxicological effects in humans and animals. Bacterial amine oxidases enzymes are determined as practical tools… read more here.
Keywords: oxidase; betahistine; glutamicibacter n1a3101; histamine ... See more keywords
Epigenetic Histone Methylation of PPARĪ³ and CPT1A Signaling Contributes to Betahistine Preventing Olanzapine-Induced Dyslipidemia
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DOI: 10.3390/ijms24119143
Abstract: As a partial histamine H1 receptor agonist and H3 antagonist, betahistine has been reported to partially prevent olanzapine-induced dyslipidemia and obesity through a combination therapy, although the underlying epigenetic mechanisms are still not known. Recent… read more here.
Keywords: histone; betahistine; cpt1a; olanzapine ... See more keywords