Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.22924
Abstract: Betulin is a lupane type pentacyclic triterpenoid, and commonly found in the bark of birch trees. It displays various pharmacological properties, such as antibacterial, anti‐inflammation, antitumor, and antiviral. In this report, we attempted to investigate… read more here.
Keywords: cell lines; mtor; osteosarcoma cell; betulin ... See more keywords
Hydrophobic and antibacterial textile fibres prepared by covalently attaching betulin to cellulose
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DOI: 10.1007/s10570-019-02265-8
Abstract: Betulin, a natural compound extractable from the outer bark of birch, can be used to improve the properties of cellulosic textile fibres. Herein, oxidation was performed to prepare carboxyl-functionalized cellulose, which was subsequently covalently attached… read more here.
Keywords: hydrophobic antibacterial; textile fibres; cellulose hydrophobic; antibacterial textile ... See more keywords
Synthesis of Betulin Dibenzoate and Diphthalate
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DOI: 10.1007/s10600-017-1976-5
Abstract: Betulin-3,28-dibenzoate and -3,28-diphthalate were synthesized for the first time by reacting betulin with melts of benzoic and phthalic acids at 190–200°C for 5 min. read more here.
Keywords: betulin dibenzoate; dibenzoate diphthalate; betulin; synthesis betulin ... See more keywords
Anti-inflammatory/Anti-apoptotic impact of Betulin Attenuates experimentally Induced Ulcerative Colitis; An insight into TLR4/NF-kB/caspase signalling modulation.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2021.103750
Abstract: Ulcerative colitis (UC) is an inflammatory bowel disease with limited therapeutic management approaches. The present study evaluated the potential therapeutic impact of betulin on acetic acid (AA)-induced UC in rats. UC was induced by intracolonic… read more here.
Keywords: caspase; inflammatory; impact betulin; ulcerative colitis ... See more keywords
Betulin alleviates cisplatin-induced hepatic injury in rats: Targeting apoptosis and Nek7-independent NLRP3 inflammasome pathways.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107925
Abstract: Cisplatin is a chemotherapeutic agent that induces multiorgan toxicity side effect due to induction of inflammation, apoptosis and disruption of intracellular antioxidant pathways. Betulin is a natural triterpenoid that has been shown to counteract cisplatin-induced… read more here.
Keywords: injury rats; cisplatin; effect; cisplatin induced ... See more keywords
Random versus Block Glycopolymers Bearing Betulin and Porphyrin for Enhanced Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00922
Abstract: Porphyrins and their derivatives, representing the second-generation photosensitizers, can generate reactive oxygen species (ROS) and kill tumors upon light irradiation. To compensate for the fluorescence quenching and reduced ROS production caused by aggregation and rigid… read more here.
Keywords: betulin porphyrin; chemistry; glycopolymers bearing; betulin ... See more keywords
Overexpression of ABCC1 Confers Drug Resistance to Betulin
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.640656
Abstract: Betulin is a lupane-type pentacyclic triterpene, which is isolated from birch bark. It has a broad spectrum of biological and pharmacological properties, such as anti-inflammatory, anti-tumor, anti-viral, and anti-bacterial activity. Herein, we explored the factors… read more here.
Keywords: abcc1 confers; overexpression abcc1; resistance; betulin ... See more keywords
Betulin Alleviates the Inflammatory Response in Mouse Chondrocytes and Ameliorates Osteoarthritis via AKT/Nrf2/HO-1/NF-κB Axis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.754038
Abstract: Osteoarthritis (OA) is a common degenerative joint disease featuring the degeneration, destruction, and ossification of cartilage. Inflammation which may facilitate OA occurrence and development is considered as the main pathological factor. Betulin, a natural product… read more here.
Keywords: alleviates inflammatory; betulin alleviates; via akt; axis betulin ... See more keywords
New Betulin Derivatives with Nitrogen Heterocyclic Moiety—Synthesis and Anticancer Activity In Vitro
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DOI: 10.3390/biom12101540
Abstract: As part of the search for new medicinal substances with potential application in oncology, the synthesis of new compounds combining the betulin molecule and the indole system was carried out. The structure of the ester… read more here.
Keywords: anticancer activity; synthesis; betulin; betulin derivatives ... See more keywords
Synthesis and Characterization of Novel Bio-Chiral Dopants Obtained from Bio-Betulin Produced by a Fermentation Process
Sign Up to like & getrecommendations! Published in 2021 at "Crystals"
DOI: 10.3390/cryst11070785
Abstract: Cholesteric liquid crystals are frequently produced by the addition of chiral dopants to achiral nematic hosts. We report here the synthesis and performance of chiral dopants obtained from bio-betulin produced by a fermentation process. An… read more here.
Keywords: obtained bio; bio betulin; chiral dopants; betulin ... See more keywords
Catalytic Sulfation of Betulin with Sulfamic Acid: Experiment and DFT Calculation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031602
Abstract: Betulin is an important triterpenoid substance isolated from birch bark, which, together with its sulfates, exhibits important bioactive properties. We report on a newly developed method of betulin sulfation with sulfamic acid in pyridine in… read more here.
Keywords: betulin; sulfamic acid; catalytic sulfation; betulin disulfate ... See more keywords