Effect of lipid type on betulin-stabilized water-in-oil Pickering emulsion: emulsion properties, in vitro digestion, and betulin bioaccessibility.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.13867
Abstract: BACKGROUND The Pickering emulsion delivery technique is widely acknowledged for its efficacy in serving as a carrier that can encapsulate functional components effectively. Previous studies have shown significant differences in the stability of Pickering emulsions… read more here.
Keywords: pickering emulsion; emulsion; betulin; bioaccessibility ... See more keywords
Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Toxicology"
DOI: 10.1002/tox.22924
Abstract: Betulin is a lupane type pentacyclic triterpenoid, and commonly found in the bark of birch trees. It displays various pharmacological properties, such as antibacterial, anti‐inflammation, antitumor, and antiviral. In this report, we attempted to investigate… read more here.
Keywords: cell lines; mtor; osteosarcoma cell; betulin ... See more keywords
Hydrophobic and antibacterial textile fibres prepared by covalently attaching betulin to cellulose
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DOI: 10.1007/s10570-019-02265-8
Abstract: Betulin, a natural compound extractable from the outer bark of birch, can be used to improve the properties of cellulosic textile fibres. Herein, oxidation was performed to prepare carboxyl-functionalized cellulose, which was subsequently covalently attached… read more here.
Keywords: hydrophobic antibacterial; textile fibres; cellulose hydrophobic; antibacterial textile ... See more keywords
Synthesis of Betulin Dibenzoate and Diphthalate
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DOI: 10.1007/s10600-017-1976-5
Abstract: Betulin-3,28-dibenzoate and -3,28-diphthalate were synthesized for the first time by reacting betulin with melts of benzoic and phthalic acids at 190–200°C for 5 min. read more here.
Keywords: betulin dibenzoate; dibenzoate diphthalate; betulin; synthesis betulin ... See more keywords
Anti-inflammatory/Anti-apoptotic impact of Betulin Attenuates experimentally Induced Ulcerative Colitis; An insight into TLR4/NF-kB/caspase signalling modulation.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2021.103750
Abstract: Ulcerative colitis (UC) is an inflammatory bowel disease with limited therapeutic management approaches. The present study evaluated the potential therapeutic impact of betulin on acetic acid (AA)-induced UC in rats. UC was induced by intracolonic… read more here.
Keywords: caspase; inflammatory; impact betulin; ulcerative colitis ... See more keywords
Betulin alleviates cisplatin-induced hepatic injury in rats: Targeting apoptosis and Nek7-independent NLRP3 inflammasome pathways.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107925
Abstract: Cisplatin is a chemotherapeutic agent that induces multiorgan toxicity side effect due to induction of inflammation, apoptosis and disruption of intracellular antioxidant pathways. Betulin is a natural triterpenoid that has been shown to counteract cisplatin-induced… read more here.
Keywords: injury rats; cisplatin; effect; cisplatin induced ... See more keywords
Random versus Block Glycopolymers Bearing Betulin and Porphyrin for Enhanced Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00922
Abstract: Porphyrins and their derivatives, representing the second-generation photosensitizers, can generate reactive oxygen species (ROS) and kill tumors upon light irradiation. To compensate for the fluorescence quenching and reduced ROS production caused by aggregation and rigid… read more here.
Keywords: betulin porphyrin; chemistry; glycopolymers bearing; betulin ... See more keywords
Betulin-NLC-hydrogel for the Treatment of Psoriasis-like Skin Inflammation: Optimization, Characterisation, and In vitro and In vivo Evaluation.
Sign Up to like & getrecommendations! Published in 2024 at "Current drug delivery"
DOI: 10.2174/0115672018329544240922151617
Abstract: PURPOSE Psoriasis is a chronic inflammatory skin disorder that poses significant challenges regarding effective and targeted drug delivery. Bioactive substances like betulin have shown tremendous utility in treating these conditions; however, they pose limited utility… read more here.
Keywords: nlc hydrogel; betulin nlc; drug; psoriasis ... See more keywords
Overexpression of ABCC1 Confers Drug Resistance to Betulin
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.640656
Abstract: Betulin is a lupane-type pentacyclic triterpene, which is isolated from birch bark. It has a broad spectrum of biological and pharmacological properties, such as anti-inflammatory, anti-tumor, anti-viral, and anti-bacterial activity. Herein, we explored the factors… read more here.
Keywords: abcc1 confers; overexpression abcc1; resistance; betulin ... See more keywords
Betulin Alleviates the Inflammatory Response in Mouse Chondrocytes and Ameliorates Osteoarthritis via AKT/Nrf2/HO-1/NF-κB Axis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.754038
Abstract: Osteoarthritis (OA) is a common degenerative joint disease featuring the degeneration, destruction, and ossification of cartilage. Inflammation which may facilitate OA occurrence and development is considered as the main pathological factor. Betulin, a natural product… read more here.
Keywords: alleviates inflammatory; betulin alleviates; via akt; axis betulin ... See more keywords
New Betulin Derivatives with Nitrogen Heterocyclic Moiety—Synthesis and Anticancer Activity In Vitro
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101540
Abstract: As part of the search for new medicinal substances with potential application in oncology, the synthesis of new compounds combining the betulin molecule and the indole system was carried out. The structure of the ester… read more here.
Keywords: anticancer activity; synthesis; betulin; betulin derivatives ... See more keywords