Synthesis and cytotoxicity of betulin and betulinic acid derived 30-oxo-amides
Sign Up to like & getrecommendations! Published in 2022 at "Steroids"
DOI: 10.1016/j.steroids.2022.109014
Abstract: Betulin and betulinic acid derived 30-oxo-amides were prepared by hydroboration, subsequent oxidation and amidation; these novel compounds were screened for their cytotoxic activity by SRB assays. All of the compounds showed significant cytotoxic activity for… read more here.
Keywords: betulinic acid; oxo amides; derived oxo; betulin betulinic ... See more keywords
Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00679
Abstract: Betulin and betulinic acid have been widely studied for their anticancer activities. However, their further development is limited due to low bioavailability, poor aqueous solubility, and limited intracellular accumulation. In the present study, a triphenylphosphonium… read more here.
Keywords: lupane triterpenoid; mitochondria targeted; betulin betulinic; betulinic acid ... See more keywords
Neuroprotective properties of Betulin, Betulinic acid, and Ursolic acid as triterpenoids derivatives: a comprehensive review of mechanistic studies.
Sign Up to like & getrecommendations! Published in 2023 at "Nutritional neuroscience"
DOI: 10.1080/1028415x.2023.2180865
Abstract: Cognitive deficits are the main outcome of neurological disorders whose occurrence has risen over the past three decades. Although there are some pharmacologic approaches approved for managing neurological disorders, it remains largely ineffective. Hence, exploring… read more here.
Keywords: betulin betulinic; neurological disorders; ursolic acid; acid ... See more keywords
Biological Activity and In Silico Study of 3-Modified Derivatives of Betulin and Betulinic Aldehyde
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20061372
Abstract: A series of 3-substituted derivatives of betulin and betulinic aldehyde were synthesized as promising anticancer agents. The newly triterpenes were tested against five human cancer cell lines like biphenotypic B myelomonocytic leukaemia (MV-4-11), adenocarcinoma (A549),… read more here.
Keywords: biological activity; betulin betulinic; activity silico; betulinic aldehyde ... See more keywords