Design, synthesis and biological activity of 1,4-quinone moiety attached to betulin derivatives as potent DT-diaphorase substrate.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104478
Abstract: In this research, betulin derivatives were bonded to the 1,4-quinone fragment by triazole linker. Furthermore, the enzymatic assay used has shown that these compounds are a good DT-diaphorase (NQO1) substrates as evidenced by increasing enzymatic… read more here.
Keywords: betulin derivatives; quinone moiety; activity;
Novel betulin derivatives inhibit IFN-γ and modulates COX-2 expression
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1528581
Abstract: Abstract Betulin (BE) is a pentacyclic triterpenes, obtained from natural sources and with several biological activities described, such as anti-tumoral and anti-inflammatory activities. The BE esterification at hydroxyl group (C-3 and C-28) resulted in five… read more here.
Keywords: derivatives inhibit; cox expression; betulin derivatives; expression ... See more keywords
Application of TLC for Evaluation of the Lipophilicity of Newly Synthetized Esters: Betulin Derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Analytical Methods in Chemistry"
DOI: 10.1155/2019/1297659
Abstract: The problem of designing a new drug is nowadays very important for researches representing many branches of science. This work considers the usefulness of the analytical method such as thin-layer chromatography for the lipophilicity of… read more here.
Keywords: lipophilicity; tlc evaluation; value; application tlc ... See more keywords
New Betulin Derivatives with Nitrogen Heterocyclic Moiety—Synthesis and Anticancer Activity In Vitro
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DOI: 10.3390/biom12101540
Abstract: As part of the search for new medicinal substances with potential application in oncology, the synthesis of new compounds combining the betulin molecule and the indole system was carried out. The structure of the ester… read more here.
Keywords: anticancer activity; synthesis; betulin; betulin derivatives ... See more keywords
Synthesis and Anticancer Activity of Indole-Functionalized Derivatives of Betulin
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DOI: 10.3390/pharmaceutics14112372
Abstract: Pentacyclic triterpenes, including betulin, are widespread natural products with various pharmacological effects. These compounds are the starting material for the synthesis of substances with promising anticancer activity. The chemical modification of the betulin scaffold that… read more here.
Keywords: betulin; anticancer activity; betulin derivatives; indole betulin ... See more keywords
Morphology of Lymphoid Tissue in the Lungs of Guinea Pigs Infected with Mycobacterium bovis against the Background of Vaccine Immunity and the Action of Betulin and Its Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10122084
Abstract: Tuberculosis caused by Mycobacterium bovis is a serious problem for animal and human health worldwide. A promising concept for the design of anti-tuberculosis drugs is the conjugation of an immunogenic fraction isolated from bacterial vaccines… read more here.
Keywords: immunity action; lymphoid tissue; mycobacterium bovis; betulin ... See more keywords