Betulinic acid: A natural promising anticancer drug, current situation, and future perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23206
Abstract: Natural products serve as the single most productive source for the discovery of drugs and pharmaceutical leads. Among the various chemicals derived from microbes, plants, and animals, phytochemicals have emerged as potential candidates for the… read more here.
Keywords: anticancer drug; natural promising; drug current; promising anticancer ... See more keywords
Study on the metabolites of betulinic acid in vivo and in vitro by ultra high performance liquid chromatography with time-of-flight mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of separation science"
DOI: 10.1002/jssc.201800960
Abstract: Betulinic acid is a triterpenoid organic acid with remarkable antitumor properties and is naturally present in many fruits, condiments and traditional Chinese medicines. Currently, a strategy was developed for the identification of metabolites following the… read more here.
Keywords: vivo vitro; acid; ultra high; betulinic acid ... See more keywords
Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-10004-z
Abstract: Betulinic acid (BA) and its derivatives possess potent pharmacological activity against cancer and HIV. As with many phytochemicals, access to BA is limited by the requirement for laborious extraction from plant biomass where it is… read more here.
Keywords: rocyp01 cyp716a155; production; betulinic acid;
In silico studies of interactions of peptide-conjugated cholesterol metabolites and betulinic acid with EGFR, LDR, and N-terminal fragment of CCKA receptors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Modeling"
DOI: 10.1007/s00894-021-05007-5
Abstract: In this work, we designed three new ligands by conjugating cholesterol metabolites 3-hydroxy-5-cholestenoic acid (3-HC) and 3-oxo-4-cholestenoic acid (3-OC) and the natural tri-terpenoid betulinic acid with the tumor-targeting peptide YHWYGYTPQNVI. Molecular interactions with the unconjugated… read more here.
Keywords: betulinic acid; cholesterol metabolites; acid; ccka ... See more keywords
Synthesis and Cytotoxicity of Conjugates of Betulinic Acid and F-Containing 2-Acylcycloalkane-1,3-Diones
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Natural Compounds"
DOI: 10.1007/s10600-018-2565-y
Abstract: Conjugates of betulinic acid with 2-(fluoroacyl)cycloalkane-1,3-dione motifs were synthesized by reacting 3-chloro-2-(fluoroacyl)-2-cycloalkene-1-ones with an equivalent amount of betulinic acid aminoalkylamide hydrochlorides in the presence of Et3N in CHCl3. Reduction of betulonic acid conjugates with 2-trifluoroacetylcyclopentane-1,3-dione… read more here.
Keywords: synthesis cytotoxicity; conjugates betulinic; cytotoxicity conjugates; betulinic acid ... See more keywords
Synthesis of a new betulinic acid glycoconjugate with N-acetyl-d-galactosamine for the targeted delivery to hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-020-2737-3
Abstract: A new promising conjugate of betulinic acid with N-acetyl-d-galactosamine was synthesized by the simple reaction sequence: esterification and copper-catalyzed azide-alkyne cycloaddition. The obtained glycoderivative exhibited high activity against hepatocarcinoma cell lines in vitro, selectivity of… read more here.
Keywords: acetyl galactosamine; synthesis new; betulinic acid;
Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice
Sign Up to like & getrecommendations! Published in 2017 at "Current Medical Science"
DOI: 10.1007/s11596-017-1798-5
Abstract: SummaryIschemic stroke leads to high potentiality of mortality and disability. The current treatment for ischemic stroke is mainly focused on intravenous thrombolytic therapy. However, ischemia/ reperfusion induces neuronal damage, which significantly influences the outcome of… read more here.
Keywords: cerebral ischemia; betulinic acid; reperfusion; ischemia reperfusion ... See more keywords
The effects of betulinic acid on neurobehavioral activity, electrophysiology and histological changes in an animal model of the Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.10.002
Abstract: HighlightsBetulinic acid could prevent neurobehavioral deficits in AD‐induced rats.Betulinic acid could prevent LTP deficits in AD‐induced rats.There is the best effect of 1:4 molar ratio toward A&bgr; to BA interaction.Congo‐red staining showed reduced A&bgr; fibril… read more here.
Keywords: injection vehicle; mgr rat; alzheimer disease; histological changes ... See more keywords
Effect of betulinic acid and its ionic derivatives on M-MuLV replication.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.080
Abstract: Murine leukemia virus (MuLV) is a retrovirus known causing leukemia and neurological disorders in mice, and its viral life cycle and pathogenesis have been investigated extensively over the past decades. As a natural antiviral agent,… read more here.
Keywords: 43d cells; betulinic acid; ionic derivatives; acid ionic ... See more keywords
A betulinic acid derivative SH479 inhibits collagen‐induced arthritis by modulating T cell differentiation and cytokine balance
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.12.006
Abstract: Abstract The ideal therapeutic drug for rheumatoid arthritis (RA) should not only inhibit inflammation, but also prevent articular joint damage and particularly inhibit osteoclastogenesis. Betulinic acid (BA) is a natural pentacyclic triterpene that has displayed… read more here.
Keywords: sh479; betulinic acid; effect; arthritis ... See more keywords
Glycerol improves heterologous biosynthesis of betulinic acid in engineered Yarrowia lipolytica
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Engineering Science"
DOI: 10.1016/j.ces.2018.10.052
Abstract: Abstract Glycerol is the main byproduct of the biodiesel production process and can be converted into valuable products by Yarrowia lipolytica. Betulinic acid is a pentacyclic triterpene with a variety of pharmacological properties. Herein we… read more here.
Keywords: glycerol; betulinic acid; heterologous biosynthesis; yarrowia lipolytica ... See more keywords