Bevacizumab induces oxidative cytotoxicity and apoptosis via TRPM2 channel activation in retinal pigment epithelial cells: Protective role of glutathione
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DOI: 10.1007/s00417-021-05074-7
Abstract: Bevacizumab (BEV) is a blocker of circulating VEGF A generation. However, BEV has adverse apoptotic and cytotoxic effects via upregulation of mitochondrial reactive oxygen species (ROS) and TRPM2 activation, and downregulation of cytosolic glutathione (GSH)… read more here.
Keywords: pigment epithelial; treatment; gsh; bev ... See more keywords
CIRP regulates BEV-induced cell migration in gliomas
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DOI: 10.2147/cmar.s191249
Abstract: Purpose A better understanding of the underlying molecular mechanisms in treatment failure of bevacizumab (BEV) for malignant glioma would contribute to overcome therapeutic resistance. Methods Here, we used a quantitative proteomic method to identify molecular… read more here.
Keywords: cirp; bev induced; cell; cell migration ... See more keywords
CIRP Regulates BEV-Induced Cell Migration in Gliomas [Corrigendum]
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DOI: 10.2147/cmar.s264765
Abstract: [This corrects the article DOI: 10.2147/CMAR.S191249.]. read more here.
Keywords: migration gliomas; cirp regulates; cell migration; bev induced ... See more keywords