Metabolism and disposition of the SGLT2 inhibitor bexagliflozin in rats, monkeys and humans
Sign Up to like & getrecommendations! Published in 2019 at "Xenobiotica"
DOI: 10.1080/00498254.2019.1654634
Abstract: Abstract Bexagliflozin is a C-aryl glucoside inhibitor of human sodium-glucose linked transporter 2 (SGLT2) that undergoes oxidation and glucuronidation to form six principal metabolites in humans. In vitro metabolism by human liver microsomes and recombinant… read more here.
Keywords: monkeys humans; inhibitor; metabolism; bexagliflozin ... See more keywords
Safety and effectiveness of the sodium‐glucose cotransporter inhibitor bexagliflozin in cats newly diagnosed with diabetes mellitus
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DOI: 10.1111/jvim.16730
Abstract: Abstract Background Bexagliflozin is a sodium‐glucose cotransporter 2 (SGLT2) inhibitor. A pilot study has shown that bexagliflozin can decrease dependence on exogenous insulin in cats with diabetes mellitus (DM). Objective To evaluate the safety and… read more here.
Keywords: safety; safety effectiveness; glucose cotransporter; diabetes mellitus ... See more keywords