Ex Vivo Investigation of Bexarotene and Nicotinamide Function as a Protectıve Agent on Rat Synaptosomes Treated with Aβ(1-42).
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-020-03216-7
Abstract: In this study, we were aimed to investigate the neuroprotective effects of bexarotene and nicotinamide in synaptosomes incubated with amyloid-beta (Aβ). Our study consists of 2 parts, in vivo and in vitro. In the in… read more here.
Keywords: bexarotene nicotinamide; vivo investigation; investigation bexarotene; bexarotene ... See more keywords
New highly cytotoxic organic and organometallic bexarotene derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2017.03.031
Abstract: Abstract A series of bifunctional ruthenium(II) arene compounds modified with bexarotene, a retinoid that selectively activates retinoid X receptors inducing cell differentiation and apoptosis and preventing drug resistance, are described. The bexarotene is tethered to… read more here.
Keywords: new highly; cytotoxic organic; bexarotene; organic organometallic ... See more keywords
Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study
Sign Up to like & getrecommendations! Published in 2021 at "The Lancet Neurology"
DOI: 10.1016/s1474-4422(21)00179-4
Abstract: BACKGROUND Progressive disability in multiple sclerosis occurs because CNS axons degenerate as a late consequence of demyelination. In animals, retinoic acid receptor RXR-gamma agonists promote remyelination. We aimed to assess the safety and efficacy of… read more here.
Keywords: placebo; efficacy; bexarotene; multiple sclerosis ... See more keywords
Morphology, in vivo distribution and antitumor activity of bexarotene nanocrystals in lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2016.1225752
Abstract: Abstract The objective of this study was to develop and evaluate the morphology, biodistribution and antitumor activity of bexarotene nanocrystals delivery system. The morphology was investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM),… read more here.
Keywords: microscopy; antitumor activity; morphology; bexarotene ... See more keywords
PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aal2332
Abstract: PPARδ activation by bexarotene in a mouse model of Huntington’s disease rescues defective oxidative metabolism and is neuroprotective. Defeating neurotoxicity with a repurposed drug PPARδ is a permissive nuclear receptor that heterodimerizes with the retinoid… read more here.
Keywords: ppar; quality control; ppar activation; bexarotene ... See more keywords
Bexarotene normalizes chemotherapy-induced myelin decompaction and reverses cognitive and sensorimotor deficits in mice
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-01061-x
Abstract: Frequently reported neurotoxic sequelae of cancer treatment include cognitive deficits and sensorimotor abnormalities that have long-lasting negative effects on the quality of life of an increasing number of cancer survivors. The underlying mechanisms are not… read more here.
Keywords: cognitive sensorimotor; treatment; cisplatin; sensorimotor ... See more keywords
Mogamulizumab and bexarotene are a promising association for the treatment of advanced cutaneous T-cell lymphomas: a case series.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202211_30166
Abstract: BACKGROUND Treatment choices for patients with advanced-stage mycosis fungoides (MF) or Sézary syndrome (SS) who have failed first-line systemic therapies can be challenging, as several options are available. However, most evidence is based on observational… read more here.
Keywords: mogamulizumab; bexarotene; treatment; bexarotene promising ... See more keywords
Bexarotene Reduces Production of CCL22 From Tumor-Associated Macrophages in Cutaneous T-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00907
Abstract: Bexarotene is a third-generation retinoid X receptor-selective retinoid that has been approved for use in the treatment of both early and advanced cutaneous T-cell lymphoma (CTCL). Although bexarotene has been used for decades in the… read more here.
Keywords: tumor; ccl22; production ccl22; bexarotene ... See more keywords
Cocrystal Prediction of Bexarotene by Graph Convolution Network and Bioavailability Improvement
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14102198
Abstract: Bexarotene (BEX) was approved by the FDA in 1999 for the treatment of cutaneous T-cell lymphoma (CTCL). The poor aqueous solubility causes the low bioavailability of the drug and thereby limits the clinical application. In… read more here.
Keywords: bexarotene; prediction bexarotene; bioavailability; bex ... See more keywords
Bexarotene enhances heart structure and function in diabetic rats by inhibiting ventricular remodeling and cardiomyocyte apoptosis
Sign Up to like & getrecommendations! Published in 2021 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v18i7.14
Abstract: Purpose: To investigate the influence of bexarotene (Bex) on cardiac structure and function in streptozotocin (STZ)-induced diabetes mellitus (DM) rats, and the mechanism of action involved. Methods: Four groups of Sprague Dawley rats (n =… read more here.
Keywords: structure function; bexarotene; structure; bcl2 bax ... See more keywords