Selective Covalent Targeting of Anti‐apoptotic BFL‐1 by a Sulfonium‐Tethered Peptide
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000473
Abstract: Anti‐apoptotic B cell lymphoma 2 (BCL‐2) family proteins are proven targets for human cancers. Targeting the BH3‐binding pockets of these anti‐apoptotic proteins could reactivate apoptosis in BCL‐2‐depedent cancers. BFL‐1 is a BCL‐2 family protein overexpressed… read more here.
Keywords: sulfonium tethered; tethered peptide; bfl; anti apoptotic ... See more keywords
Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.08.089
Abstract: Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality. Thus, intensive drug development efforts have focused on targeting this class of oncogenic proteins to… read more here.
Keywords: bfl; precision targeting; human cancer; bfl atm ... See more keywords
Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.04.004
Abstract: The BCL-2 family is composed of anti- and pro-apoptotic members that respectively protect or disrupt mitochondrial integrity. Anti-apoptotic overexpression can promote oncogenesis by trapping the BCL-2 homology 3 (BH3) "killer domains" of pro-apoptotic proteins in… read more here.
Keywords: disulfide tethering; covalent molecular; identification covalent; bfl ... See more keywords
Last but not least: BFL-1 as an emerging target for anti-cancer therapies
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20220153
Abstract: BFL-1 is an understudied pro-survival BCL-2 protein. The expression of BFL-1 is reported in many cancers, but it is yet to be clarified whether high transcript expression also always correlates with a pro-survival function. However,… read more here.
Keywords: bfl; last least; least bfl; bfl emerging ... See more keywords
A Fast Blockchain-Based Federated Learning Framework With Compressed Communications
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Journal on Selected Areas in Communications"
DOI: 10.1109/jsac.2022.3213345
Abstract: Recently, blockchain-based federated learning (BFL) has attracted intensive research attention due to that the training process is auditable and the architecture is serverless avoiding the single point failure of the parameter server in vanilla federated… read more here.
Keywords: bfl; blockchain based; federated learning; fast blockchain ... See more keywords
The pivotal role of Bifida Ferment Lysate on reinforcing the skin barrier function and maintaining homeostasis of skin defenses in vitro.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cosmetic dermatology"
DOI: 10.1111/jocd.15831
Abstract: BACKGROUND The semiactive or inactive probiotics or their extracts used in dermatology have interesting properties to ameliorate signs of irritated skin and enhance the skin barrier. Bifidobacterium, as the most common probiotics, which has been… read more here.
Keywords: barrier function; skin barrier; bfl; barrier ... See more keywords
Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3 mimetic resistance in lymphomas.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020008528
Abstract: BH3 mimetics like Venetoclax target pro-survival Bcl-2 family proteins and are important therapeutics in the treatment of hematological malignancies. We demonstrate endogenous Bfl-1 expression can render preclinical lymphoma tumor models insensitive to Mcl-1 and Bcl-2-inhibitors.… read more here.
Keywords: bfl; bh3; cdk9; targeting bfl ... See more keywords