Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
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DOI: 10.1016/j.celrep.2018.08.089
Abstract: Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality. Thus, intensive drug development efforts have focused on targeting this class of oncogenic proteins to… read more here.
Keywords: bfl; precision targeting; human cancer; bfl atm ... See more keywords