Abstract 4976: Preclinical characterization of BGI-9004, a covalent TEAD inhibitor with exceptional anti-cancer activity and combination potential
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DOI: 10.1158/1538-7445.am2023-4976
Abstract: Pharmacological inhibitors of TEAD transcription factors have emerged as a promising novel class of anti-cancer agents. TEAD inhibitors disrupt oncogenic YAP/TAZ signaling, resulting in cell cycle arrest and cell death in susceptible cancers. In preclinical… read more here.
Keywords: anti cancer; tead; activity; bgi 9004 ... See more keywords