Oleanolic acid protects against cognitive decline and neuroinflammation‐mediated neurotoxicity by blocking secretory phospholipase A2 IIA‐activated calcium signals
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DOI: 10.1016/j.molimm.2018.04.015
Abstract: HIGHLIGHTSOleanolic acid suppresses inflammatory response in A&bgr;‐activated astrocyte.OA attenuates A&bgr;‐stimulated astrocytes‐induced neuronal growth inhibition.OA restrains A&bgr;‐induced expression and release of sPLA2‐IIA.OA protects against A&bgr;‐induced neurotoxicity by blocking sPLA2‐IIA‐evoked Ca2+ influx.OA ameliorates cognitive deficits and inflammatory… read more here.
Keywords: bgr activated; neurotoxicity; acid; iia ... See more keywords