Free‐fatty acid receptor‐4 (FFA4) modulates ROS generation and COX‐2 expression via the C‐terminal &bgr;‐arrestin phosphosensor in Raw 264.7 macrophages
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DOI: 10.1016/j.bcp.2017.09.008
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Agonism of the G protein‐coupled free‐fatty acid receptor‐4 (FFA4) has been shown to promote numerous anti‐inflammatory effects in macrophages that arise due to interaction with &bgr;‐arrestin partner proteins.… read more here.
Keywords: bgr arrestin; ffa4; bgr; arrestin phosphosensor ... See more keywords
Assessments of cellular melatonin receptor signaling pathways: &bgr;‐arrestin recruitment, receptor internalization, and impedance variations
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DOI: 10.1016/j.ejphar.2017.11.022
Abstract: Abstract Melatonin receptors belong to the family of G‐protein coupled receptors. Agonist‐induced receptor activation is terminated with the recruitment of &bgr;‐arrestin, which leads to receptor internalization. Furthermore, agonist binding induces a shift in cellular shape… read more here.
Keywords: signaling pathways; receptor internalization; receptor; bgr arrestin ... See more keywords
The association of β-arrestin2 polymorphisms with response to antidepressant treatment in depressed patients
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DOI: 10.1016/j.pnpbp.2017.10.006
Abstract: &NA; The study of genetic polymorphisms involved in antidepressants (AD) response is essential to provide a personalized medicine approach in the field of depression. &bgr;‐arrestin 2 (ARRB2) is a candidate gene in the pharmacogenetics of… read more here.
Keywords: response; treatment; association arrestin2; lower response ... See more keywords
G Protein–Coupled Receptor Signaling Through &bgr;-Arrestin–Dependent Mechanisms
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DOI: 10.1097/fjc.0000000000000482
Abstract: Abstract: &bgr;-arrestin1 (or arrestin2) and &bgr;-arrestin2 (or arrestin3) are ubiquitously expressed cytosolic adaptor proteins that were originally discovered for their inhibitory role in G protein–coupled receptor (GPCR) signaling through heterotrimeric G proteins. However, further biochemical… read more here.
Keywords: bgr; protein coupled; coupled receptor; bgr arrestin ... See more keywords