Glycine Transporter‐1 and glycine receptor mediate the antioxidant effect of glycine in diabetic rat islets and INS‐1 cells
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.05.007
Abstract: Abstract Oxidative stress is the main inducer of &bgr;‐cell damage, which underlies the pathogenesis of diabetes. Evidence suggests that glycine, a recognized antioxidant, may improve &bgr;‐cell function; however, its mechanism in protecting diabetic &bgr;‐cells against… read more here.
Keywords: bgr; receptor; bgr cell; glycine ... See more keywords
Insulin and IGF-1 receptor autocrine loops are not required for Exendin-4 induced changes to pancreatic β-cell bioenergetic parameters and metabolism in BRIN-BD11 cells
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.11.015
Abstract: HighlightsChronic GLP‐1R stimulation promotes &bgr;‐cell metabolic reprogramming.IGF‐1R and IR are important for &bgr;‐cell development, function and proliferation.GLP‐1 enhanced metabolic phenotype is independent of IR and IGF‐1R autocrine loops.Enhanced metabolism can contribute to GLP‐1 pro‐survival abilities.… read more here.
Keywords: glp; activation; receptor; autocrine loops ... See more keywords
Deficiency of S100B confers resistance to experimental diabetes in mice
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.02.030
Abstract: Abstract The calcium binding protein S100B has been implicated in diabetic neuronal and vascular complications but has not been examined in the development of diabetes. S100B knock out (S100B KO) and wild‐type (WT) mice were… read more here.
Keywords: s100b; islet; bgr cell; mice ... See more keywords
Expression of Gastrin Family Peptides in Pancreatic Islets and Their Role in &bgr;-Cell Function and Survival
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DOI: 10.1097/mpa.0000000000000983
Abstract: Objectives Modulation of cholecystokinin (CCK) receptors has been shown to influence pancreatic endocrine function. Methods We assessed the impact of the CCKA and CCKB receptor modulators, (pGlu-Gln)-CCK-8 and gastrin-17, respectively, on &bgr;-cell secretory function, proliferation… read more here.
Keywords: bgr; cck; gln cck; bgr cell ... See more keywords
&bgr; Cell Replacement Therapy: The Next 10 Years
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DOI: 10.1097/tp.0000000000001937
Abstract: Abstract &bgr; cell replacement with either pancreas or islet transplantation has progressed immensely over the last decades with current 1- and 5-year insulin independence rates of approximately 85% and 50%, respectively. Recent advances are largely… read more here.
Keywords: bgr cell; cell replacement; pancreas islet;
Intracellular lipid metabolism impairs &bgr; cell compensation during diet-induced obesity
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DOI: 10.1172/jci97702
Abstract: The compensatory proliferation of insulin-producing &bgr; cells is critical to maintaining glucose homeostasis at the early stage of type 2 diabetes. Failure of &bgr; cells to proliferate results in hyperglycemia and insulin dependence in patients.… read more here.
Keywords: metabolism; insulin; bgr cell; lipid metabolism ... See more keywords
Angiotensin II Causes &bgr;‐Cell Dysfunction Through an ER Stress‐Induced Proinflammatory Response
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DOI: 10.1210/en.2016-1879
Abstract: &NA; The metabolic syndrome is associated with an increase in the activation of the renin angiotensin system, whose inhibition reduces the incidence of new‐onset diabetes. Importantly, angiotensin II (AngII), independently of its vasoconstrictor action, causes… read more here.
Keywords: cell dysfunction; dysfunction; stress; causes bgr ... See more keywords