Trigonelline inhibits caspase 3 to protect &bgr; cells apoptosis in streptozotocin‐induced type 1 diabetic mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.08.025
Abstract: Abstract As a main active ingredient of Fenugreek, trigonelline has protective efficiency on type 2 diabetes and diabetic peripheral neuropathy in rats. This study investigates the protection of trigonelline on hyperglycemia, &bgr; cell apoptosis, and… read more here.
Keywords: trigonelline; bgr; type diabetic; bgr cells ... See more keywords
Inhibition of Notch signalling has ability to alter the proximal and distal TCR signalling events in human CD3+ &agr;&bgr; T‐cells
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DOI: 10.1016/j.molimm.2017.10.013
Abstract: HighlightsThe Notch activation may be cis or trans ligand‐dependent which are regulated by TCR signalling on human &agr;&bgr; T cells.Notch signalling has the ability to affect both the proximal and distal TCR signalling events.Inhibition of… read more here.
Keywords: notch signalling; agr bgr; bgr cells; tcr signalling ... See more keywords
The glucagon-like peptide-1 analogue liraglutide promotes autophagy through the modulation of 5′-AMP-activated protein kinase in INS-1 β-cells under high glucose conditions
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DOI: 10.1016/j.peptides.2017.07.006
Abstract: HighlightsGLP‐1 analogue liraglutide increases pancreatic &bgr;‐cells autophagy under high glucose conditions;.Liraglutide inhibits pancreatic &bgr;‐cells apoptosis under high glucose conditions;.Liraglutide may protect &bgr;‐cells from high glucose by enhancing cell autophagy;.Liraglutide promotes pancreatic &bgr;‐cells autophagy through the… read more here.
Keywords: pancreatic bgr; cells high; high glucose; bgr cells ... See more keywords
Modulating impacts of quercetin/sitagliptin combination on streptozotocin‐induced diabetes mellitus in rats
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DOI: 10.1016/j.taap.2018.12.011
Abstract: Background: Since many diabetic patients require combination therapy, the use of herbal remedies with anti‐diabetic activity represents a vital option in diabetes mellitus (DM) management. It has been reported that quercetin has hypoglycemic alongside anti‐inflammatory… read more here.
Keywords: combination; sitagliptin combination; streptozotocin; diabetes mellitus ... See more keywords