Glaucocalyxin A as a natural product increases amyloid &bgr; clearance and decreases tau phosphorylation involving the mammalian target of rapamycin signaling pathway
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DOI: 10.1097/wnr.0000000000001202
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder correlated with age, characterized by the accumulation of amyloid &bgr; (A&bgr;) plaques and neurofibrillary tangles. The mammalian target of rapamycin (mTOR) is an important protein that regulates… read more here.
Keywords: natural product; target; bgr clearance; tau phosphorylation ... See more keywords
SNPs in A&bgr; clearance proteins: Lower CSF A&bgr;1-42 levels and earlier onset of dementia in PD
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DOI: 10.1212/wnl.0000000000004705
Abstract: Objective: To evaluate whether genetic variants in &bgr;-amyloid (A&bgr;) clearance proteins are associated with CSF levels of A&bgr;1-42 on a biological level and the onset of dementia on a clinical level in Parkinson disease (PD).… read more here.
Keywords: bgr clearance; bgr; csf bgr; bgr levels ... See more keywords