Casticin protects against IL‐1&bgr;‐induced inflammation in human osteoarthritis chondrocytes
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DOI: 10.1016/j.ejphar.2018.10.051
Abstract: Abstract Casticin, an active compound isolated from Vitex rotundifolia L., was reported to possess anti‐inflammatory activity. However, the effect of casticin on inflammatory response in human osteoarthritis (OA) chondrocytes remains unclear. In the current study,… read more here.
Keywords: bgr; casticin; human osteoarthritis; bgr induced ... See more keywords
Butein inhibits IL‐1&bgr;‐induced inflammatory response in human osteoarthritis chondrocytes and slows the progression of osteoarthritis in mice
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DOI: 10.1016/j.intimp.2016.11.009
Abstract: Abstract Osteoarthritis (OA) is a progressive degenerative disease characterized by irreversible articular cartilage destruction. Butein, a polyphenolic compound isolated from the stem bark of cashews and Rhus verniciflua Stokes, has been reported to have anti‐inflammatory… read more here.
Keywords: osteoarthritis; mmp; human osteoarthritis; bgr induced ... See more keywords
Fisetin inhibits IL‐1&bgr;‐induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice
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DOI: 10.1016/j.intimp.2017.02.009
Abstract: &NA; Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and inflammation. Fisetin, a polyphenol extracted from fruits and vegetables, has been reported to have anti‐inflammatory effects. Our study aimed to investigate the… read more here.
Keywords: human osteoarthritis; bgr induced; fisetin; osteoarthritis chondrocytes ... See more keywords
The &agr;1,3‐fucosyltransferase FUT7 regulates IL‐1&bgr;‐induced monocyte‐endothelial adhesion via fucosylation of endomucin
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DOI: 10.1016/j.lfs.2017.11.017
Abstract: &NA; Monocyte‐endothelial adhesion is a hallmark feature of atherosclerosis at early stage and emerging evidence suggests that the glycosylation of vascular adhesive molecules and its ligands is involved in this process. Nevertheless, the mechanism underlying… read more here.
Keywords: bgr induced; monocyte endothelial; endothelial adhesion; induced monocyte ... See more keywords
Edaravone reduces A&bgr;‐induced oxidative damage in SH‐SY5Y cells by activating the Nrf2/ARE signaling pathway
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DOI: 10.1016/j.lfs.2019.02.025
Abstract: Aims: Edaravone potentially alleviates cognitive deficits in a mouse model of Alzheimer's disease (AD). However, the mechanism of edaravone in suppressing AD progression remains unclear. We aim to investigate the mechanism of edaravone in suppressing… read more here.
Keywords: oxidative damage; nrf2 signaling; signaling pathway; bgr induced ... See more keywords
Neuroprotective effects of cordycepin inhibit A&bgr;‐induced apoptosis in hippocampal neurons
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DOI: 10.1016/j.neuro.2018.07.008
Abstract: Graphical abstract Figure. No caption available. HighlightsOxidative stress cytotoxicity was involved in A&bgr;25–35‐induced apoptosis and this damage was rescued by cordycepin.Cordycepin can inhibit the A&bgr;25–35‐induced increased p‐Tau expression and AChE overactivity.The cytoprotection of cordycepin could… read more here.
Keywords: bgr induced; induced apoptosis; hippocampal neurons; neuroprotective effects ... See more keywords
Plumbagin inhibits amyloid-&bgr;-induced neurotoxicity: regulation of oxidative stress and nuclear factor erythroid 2-related factor 2 activation
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DOI: 10.1097/wnr.0000000000001103
Abstract: &bgr;-Amyloid (A&bgr;) species probably exert neurotoxic effects in Alzheimer’s disease. In the present study, the effect of antioxidant plumbagin was tested against A&bgr;25–35-induced neurotoxicity in the SH-SY5Y cell line. Cell viability was determined using an… read more here.
Keywords: bgr; plumbagin; bgr induced; nuclear factor ... See more keywords