Differential protective effects of connective tissue growth factor against A&bgr; neurotoxicity on neurons and glia
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx278
Abstract: &NA; Impaired clearance of amyloid‐&bgr; peptide (A&bgr;) leads to abnormal extracellular accumulation of this neurotoxic protein that drives neurodegeneration in sporadic Alzheimer's disease (AD). Connective tissue growth factor (CTGF/CCN2) expression is elevated in plaque‐surrounding astrocytes… read more here.
Keywords: tissue growth; bgr; connective tissue; growth factor ... See more keywords