Impaired TGF‐&bgr; signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL‐22
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.04.011
Abstract: HighlightsThe transcription of TGF‐&bgr; target genes is impaired in CD3+ lymphocytes of active SLE patients.The TGF‐&bgr; signaling defect did not result from an impaired TGF‐&bgr;RII expression or Smad2/3 phosphorylation.The TGF‐&bgr; signaling defect did not correlate… read more here.
Keywords: overexpression; bgr; bgr signaling; sle patients ... See more keywords
T Cell Receptor‐Regulated TGF‐&bgr; Type I Receptor Expression Determines T Cell Quiescence and Activation
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DOI: 10.1016/j.immuni.2018.03.025
Abstract: SUMMARY It is unclear how quiescence is enforced in naive T cells, but activation by foreign antigens and self‐antigens is allowed, despite the presence of inhibitory signals. We showed that active transforming growth factor &bgr;… read more here.
Keywords: bgr; quiescence; bgr signaling; receptor ... See more keywords
Molecular insights into the differences in anti‐inflammatory activities of green tea catechins on IL‐1&bgr; signaling in rheumatoid arthritis synovial fibroblasts
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DOI: 10.1016/j.taap.2017.05.016
Abstract: &NA; In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL‐1&bgr; signaling pathway which regulates the expression of pro‐inflammatory mediators (IL‐6 and IL‐8) and Cox‐2… read more here.
Keywords: anti inflammatory; green tea; bgr signaling; tea ... See more keywords
MicroRNA-21 Knockout Exacerbates Angiotensin II–Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-&bgr;–SMAD3 Signaling
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DOI: 10.1161/atvbaha.117.310694
Abstract: Objective— Thoracic aortic aneurysm and dissection (TAAD) are severe vascular conditions. Dysfunctional transforming growth factor-&bgr; (TGF-&bgr;) signaling in vascular smooth muscle cells and elevated angiotensin II (AngII) levels are implicated in the development of TAAD.… read more here.
Keywords: bgr signaling; mir; taad; mice ... See more keywords