Activation of GSK3&bgr;/&bgr;‐TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy
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DOI: 10.1016/j.freeradbiomed.2018.04.550
Abstract: ABSTRACT NF‐E2 p45‐related factor 2 (Nrf2), is a major redox sensitive transcription factor that plays an essential role in regulating glucose metabolism. Inactivation of Nrf2 has been associated with diabetic complications however, mechanisms warranting Nrf2… read more here.
Keywords: bgr trcp; bgr; phlpp1; gsk3 bgr ... See more keywords