Differences in the Association of BH3-Only Proteins to Biological Membranes
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1135
Abstract: Apoptosis, a prevalent mechanism of programmed cell death, is regulated by the Bcl-2 protein family. The balance between pro- and anti-apoptotic Bcl-2 members in the mitochondrial outer membrane (MOM) protects or triggers MOM permeabilization. Bcl-2… read more here.
Keywords: bh3 proteins; bh3; differences association; association bh3 ... See more keywords
IDENTIFICATION OF POTENT BH3-MIMETIC COMBINATIONS TARGETING PRO-SURVIVAL PATHWAYS IN HUMAN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.411
Abstract: Precursor-B acute lymphoblastic leukemia (B-ALL) is an aggressive hematological malignancy. Relapsed disease has a poor prognosis despite improved outcomes with tyrosine kinase inhibitors (TKIs) and immunotherapeutic approaches such as CAR-T cells. Targeting cell survival with… read more here.
Keywords: bh3 mimetic; acute lymphoblastic; bh3; lymphoblastic leukemia ... See more keywords
Importance of Hypericin-Bcl2 interactions for biological effects at subcellular levels.
Sign Up to like & getrecommendations! Published in 2019 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2019.08.016
Abstract: Hypericin (Hyp) is a naturally occurring compound used as photosensitizer in photodynamic therapy and diagnosis. Recently, we have shown that Hyp presence alone, without illumination, resulted in substantial biological effects at several sub-cellular levels. Hyp… read more here.
Keywords: hyp; bh3; hypericin; bcl2 ... See more keywords
Characterization of an alternative BAK-binding site for BH3 peptides
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17074-y
Abstract: Many cellular stresses are transduced into apoptotic signals through modification or up-regulation of the BH3-only subfamily of BCL2 proteins. Through direct or indirect mechanisms, these proteins activate BAK and BAX to permeabilize the mitochondrial outer… read more here.
Keywords: bmf hrk; directly activate; bh3 proteins; bh3 ... See more keywords
Structural basis of BAK activation in mitochondrial apoptosis initiation
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27851-y
Abstract: BCL-2 proteins regulate mitochondrial poration in apoptosis initiation. How the pore-forming BCL-2 Effector BAK is activated remains incompletely understood mechanistically. Here we investigate autoactivation and direct activation by BH3-only proteins, which cooperate to lower BAK… read more here.
Keywords: apoptosis initiation; activation; bak; bak activation ... See more keywords
A Practical 11B NMR Evaluation of BH3 Titer in Commercial Solutions
Sign Up to like & getrecommendations! Published in 2017 at "Synthesis"
DOI: 10.1055/s-0036-1588710
Abstract: Many reduction reactions require the use of BH3, which is commercially available as complex in many different solvents. The determination of the content of BH3 in such solutions could be an important issue when the… read more here.
Keywords: 11b nmr; practical 11b; nmr evaluation; bh3 ... See more keywords
Respective Place of Venetoclax and MCL1 BH3 Mimetics in Multiple Myeloma Treatment
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-109987
Abstract: Targeting anti-apoptotic proteins of the BCL2 family by BH3 mimetics is a new promising therapeutic approach in multiple myeloma (MM). The specific BH3 mimetic targeting BCL2, BCLXL or MCL1 trigger apoptosis and exploit the dependency… read more here.
Keywords: bh3 mimetics; bh3; mcl1; bcl2 ... See more keywords
Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3 mimetic resistance in lymphomas.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020008528
Abstract: BH3 mimetics like Venetoclax target pro-survival Bcl-2 family proteins and are important therapeutics in the treatment of hematological malignancies. We demonstrate endogenous Bfl-1 expression can render preclinical lymphoma tumor models insensitive to Mcl-1 and Bcl-2-inhibitors.… read more here.
Keywords: bfl; bh3; cdk9; targeting bfl ... See more keywords
Phylogenetic analysis of the MCL1 BH3 binding groove and rBH3 sequence motifs in the p53 and INK4 protein families
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0277726
Abstract: B-cell lymphoma 2 (Bcl-2) proteins are central, conserved regulators of apoptosis. Bcl-2 family function is regulated by binding interactions between the Bcl-2 homology 3 (BH3) motif in pro-apoptotic family members and the BH3 binding groove… read more here.
Keywords: mcl1; bh3; bh3 binding; rbh3 ... See more keywords
Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release
Sign Up to like & getrecommendations! Published in 2019 at "Materials"
DOI: 10.3390/ma12162567
Abstract: Therapeutic manipulation of the BCL-2 family using BH3 mimetics is an emerging paradigm in cancer treatment and immune modulation. For example, peptides mimicking the BIM BH3 helix can directly target the full complement of anti-… read more here.
Keywords: activating intrinsic; apoptosis; bh3; bim bh3 ... See more keywords
Structural Insight into KsBcl-2 Mediated Apoptosis Inhibition by Kaposi Sarcoma Associated Herpes Virus
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040738
Abstract: Numerous large DNA viruses have evolved sophisticated countermeasures to hijack the premature programmed cell death of host cells post-infection, including the expression of proteins homologous in sequence, structure, or function to cellular Bcl-2 proteins. Kaposi… read more here.
Keywords: herpes virus; ksbcl; apoptosis; bh3 ... See more keywords