Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-025-01514-7
Abstract: Ferroptosis and apoptosis are widely considered to be independent cell death modalities. Ferroptotic cell death is a consequence of insufficient radical detoxification and progressive lipid peroxidation, which is counteracted by glutathione peroxidase 4 (GPX4). Apoptotic… read more here.
Keywords: bh3 mimetics; ferroptotic apoptotic; apoptotic cell; cell death ... See more keywords
Comparison of putative BH3 mimetics AT-101, HA14-1, sabutoclax and TW-37 with ABT-737 in platelets
Sign Up to like & getrecommendations! Published in 2020 at "Platelets"
DOI: 10.1080/09537104.2020.1724276
Abstract: Abstract Platelet lifespan is regulated by intrinsic apoptosis. Platelet apoptosis can be triggered by BH3 mimetics that inhibit the pro-survival Bcl-2 family protein, Bcl-xL. Here, we investigated several small molecules that are reported to act… read more here.
Keywords: ha14; sabutoclax; abt 737; bh3 mimetics ... See more keywords
Apoptotic resistance in chronic lymphocytic leukemia and therapeutic perspectives
Sign Up to like & getrecommendations! Published in 2019 at "Critical Reviews in Clinical Laboratory Sciences"
DOI: 10.1080/10408363.2019.1600468
Abstract: Abstract Increased resistance to apoptosis represents a key oncogenic mechanism in chronic lymphocytic leukemia (CLL) that has been attributed to the upregulation of the anti-apoptotic B cell lymphoma 2 (Bcl-2) family members. Such an observation… read more here.
Keywords: apoptotic resistance; lymphocytic leukemia; bh3 mimetics; chronic lymphocytic ... See more keywords
BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac199
Abstract: BACKGROUND Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and a mitogen-activated protein kinase (MAPK)-driven disease. Oncogenic MAPK-signaling drives the majority of cells into oncogene-induced senescence (OIS). While OIS induces resistance to anti-proliferative… read more here.
Keywords: bh3 mimetics; senescent cells; bcl; pilocytic astrocytoma ... See more keywords
Sensitivity of canine hematological cancers to BH3 mimetics
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16587
Abstract: Abstract Background Inhibition of antiapoptotic B‐cell lymphoma 2 (BCL2) proteins by small molecule Bcl‐2 homology 3 (BH3) mimetics causes rapid induction of apoptosis of human hematological cancers in vitro and in vivo. Objectives Assess in… read more here.
Keywords: cell; bcl2 protein; sensitivity; bh3 mimetics ... See more keywords
Comparative analysis of Bcl-2 family protein overexpression in CAR T cells alone and in combination with BH3 mimetics
Sign Up to like & getrecommendations! Published in 2024 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.adk7640
Abstract: Approximately 50% of patients with hematologic malignancies relapse after chimeric antigen receptor (CAR) T cell treatment; mechanisms of failure include loss of CAR T persistence and tumor resistance to apoptosis. We hypothesized that both of… read more here.
Keywords: bh3 mimetics; bcl family; car; car cells ... See more keywords
Abstract 4098: Chimeric antigen receptor (CAR) T cells overexpressing Bcl-xL increase proliferation and antitumor activity alone and in combination with BH3 mimetics
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4098
Abstract: Background: Chimeric antigen receptor (CAR) T cells have become a well-established treatment option for patients, with six products approved for different hematologic diseases and new approvals allowing for their therapeutic use as early as second… read more here.
Keywords: cell; combination; car; bh3 mimetics ... See more keywords
Abstract 690: Investigation of BH-3 mimetics as radiosensitizing agents in glioblastoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-690
Abstract: Glioblastoma (GBM) is a highly aggressive primary brain tumor. Treatment consists of maximal safe tumor resection, chemotherapy (temozolomide) and radiotherapy; however, this aggressive treatment offers only a modest improvement in outcomes, with average life expectancy… read more here.
Keywords: treatment; bh3 mimetics; radiotherapy; gbm ... See more keywords
Respective Place of Venetoclax and MCL1 BH3 Mimetics in Multiple Myeloma Treatment
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-109987
Abstract: Targeting anti-apoptotic proteins of the BCL2 family by BH3 mimetics is a new promising therapeutic approach in multiple myeloma (MM). The specific BH3 mimetic targeting BCL2, BCLXL or MCL1 trigger apoptosis and exploit the dependency… read more here.
Keywords: bh3 mimetics; bh3; mcl1; bcl2 ... See more keywords
BCL2 inhibitors and MCL1 inhibitors for hematological malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020006785
Abstract: BCL2 and MCL1 are commonly expressed pro-survival (anti-apoptotic) proteins in hematological cancers and play important roles in their biology either through dysregulation or by virtue of intrinsic importance to the cell-of-origin of the malignancy. A… read more here.
Keywords: bcl2 inhibitors; mcl1 inhibitors; bh3 mimetics; inhibitors mcl1 ... See more keywords
BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14398
Abstract: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, Schwann cell-derived neoplasms of the peripheral nervous system that have recently been shown to possess an autocrine CXCL12/CXCR4 signaling loop that promotes tumor cell proliferation and survival.… read more here.
Keywords: malignant peripheral; peripheral nerve; cxcl12 expression; bh3 mimetics ... See more keywords