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Published in 2020 at "Platelets"
DOI: 10.1080/09537104.2020.1724276
Abstract: Abstract Platelet lifespan is regulated by intrinsic apoptosis. Platelet apoptosis can be triggered by BH3 mimetics that inhibit the pro-survival Bcl-2 family protein, Bcl-xL. Here, we investigated several small molecules that are reported to act…
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Keywords:
ha14;
sabutoclax;
abt 737;
bh3 mimetics ... See more keywords
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Published in 2019 at "Critical Reviews in Clinical Laboratory Sciences"
DOI: 10.1080/10408363.2019.1600468
Abstract: Abstract Increased resistance to apoptosis represents a key oncogenic mechanism in chronic lymphocytic leukemia (CLL) that has been attributed to the upregulation of the anti-apoptotic B cell lymphoma 2 (Bcl-2) family members. Such an observation…
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Keywords:
apoptotic resistance;
lymphocytic leukemia;
bh3 mimetics;
chronic lymphocytic ... See more keywords
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Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac199
Abstract: BACKGROUND Pilocytic astrocytoma (PA) is the most common pediatric brain tumor and a mitogen-activated protein kinase (MAPK)-driven disease. Oncogenic MAPK-signaling drives the majority of cells into oncogene-induced senescence (OIS). While OIS induces resistance to anti-proliferative…
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Keywords:
bh3 mimetics;
senescent cells;
bcl;
pilocytic astrocytoma ... See more keywords
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Published in 2022 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16587
Abstract: Abstract Background Inhibition of antiapoptotic B‐cell lymphoma 2 (BCL2) proteins by small molecule Bcl‐2 homology 3 (BH3) mimetics causes rapid induction of apoptosis of human hematological cancers in vitro and in vivo. Objectives Assess in…
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Keywords:
cell;
bcl2 protein;
sensitivity;
bh3 mimetics ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4098
Abstract: Background: Chimeric antigen receptor (CAR) T cells have become a well-established treatment option for patients, with six products approved for different hematologic diseases and new approvals allowing for their therapeutic use as early as second…
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Keywords:
cell;
combination;
car;
bh3 mimetics ... See more keywords
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Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-109987
Abstract: Targeting anti-apoptotic proteins of the BCL2 family by BH3 mimetics is a new promising therapeutic approach in multiple myeloma (MM). The specific BH3 mimetic targeting BCL2, BCLXL or MCL1 trigger apoptosis and exploit the dependency…
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Keywords:
bh3 mimetics;
bh3;
mcl1;
bcl2 ... See more keywords
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Published in 2021 at "Blood"
DOI: 10.1182/blood.2020006785
Abstract: BCL2 and MCL1 are commonly expressed pro-survival (anti-apoptotic) proteins in hematological cancers and play important roles in their biology either through dysregulation or by virtue of intrinsic importance to the cell-of-origin of the malignancy. A…
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Keywords:
bcl2 inhibitors;
mcl1 inhibitors;
bh3 mimetics;
inhibitors mcl1 ... See more keywords
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Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14398
Abstract: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, Schwann cell-derived neoplasms of the peripheral nervous system that have recently been shown to possess an autocrine CXCL12/CXCR4 signaling loop that promotes tumor cell proliferation and survival.…
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Keywords:
malignant peripheral;
peripheral nerve;
cxcl12 expression;
bh3 mimetics ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213751
Abstract: The treatment of young patients with Hodgkin lymphoma (HL) is often successful but a significant proportion of patients suffers from late toxicity. In the current era there are new opportunities for less toxic and more…
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Keywords:
navitoclax promising;
hodgkin lymphoma;
anti apoptotic;
combination ... See more keywords