Abstract 162: Individualizing treatment using patient derived organoids, BH3 profiling and microfluidics: A proof of concept in a patient with low-grade serous ovarian carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-162
Abstract: Background N of 1 treatment paradigms represent the pinnacle of personalized medicine in which a patient’s tumors are profiled to guide treatment. Low-grade serous ovarian cancer (LGSC) is a distinct subtype of ovarian cancer, comprising… read more here.
Keywords: proof concept; bh3 profiling; patient; viability ... See more keywords
Individualized Mitochondrial Functional Approach to Combination of BCL-2 and MCL-1 Antagonism in Acute Myeloid Leukemia
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DOI: 10.1182/blood-2019-131101
Abstract: BCL-2 antagonist venetoclax combined with hypomethylating agents or low-dose cytarabine is a new standard of care for treatment-naive elderly or unfit AML patients. Despite the striking overall response of 70%, only 30% achieved MRD negative… read more here.
Keywords: combination; venetoclax; bh3 profiling; research funding ... See more keywords
Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling
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DOI: 10.3390/cancers13051002
Abstract: Simple Summary The BCL2 protein is expressed in many non-Hodgkin lymphomas (NHLs) as well as associated leukemias, e.g., chronic lymphocytic leukemia (CLL). It functions as a cell survival protein that reduces that ability of a… read more here.
Keywords: lymphoma; venetoclax; apoptosis; non hodgkin ... See more keywords
BH3 profiling discriminates the anti-apoptotic status of 5-fluorouracil-resistant colon cancer cells
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DOI: 10.3892/or.2019.7373
Abstract: 5-Fluorouracil (5-FU) is a cytotoxic anticancer drug commonly used for patients with advanced colon cancer. This drug effectively reduces the size of tumors to a certain degree; however, cancer cells can gradually acquire resistance, resulting… read more here.
Keywords: bh3 profiling; resistance; colon cancer; resistant colon ... See more keywords