Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output
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DOI: 10.1007/s00018-019-03091-8
Abstract: Bcl-2 proteins have emerged as critical regulators of intracellular Ca2+ dynamics by directly targeting and inhibiting the IP3 receptor (IP3R), a major intracellular Ca2+-release channel. Here, we demonstrate that such inhibition occurs under conditions of basal,… read more here.
Keywords: bh4 domain; ligand binding; ip3; ca2 ... See more keywords