A novel role of helix‐loop‐helix transcriptional factor Bhlhe40 in osteoclast activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30844
Abstract: The basic helix‐loop‐helix transcriptional factor, Bhlhe40 has been shown as a crucial regulator of immune response, tumorigenesis, and circadian rhythms. We identified Bhlhe40 as a possible regulator of osteoclast differentiation and function by shRNA library… read more here.
Keywords: bhlhe40; loop helix; bone; helix loop ... See more keywords
Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.10.009
Abstract: PGC-1α is a key regulator of oxidative metabolism facilitating the expression of genes critical for the function and biogenesis of the two key oxidative organelles, mitochondria and peroxisomes, in skeletal muscle (SKM) and other organs.… read more here.
Keywords: oxidative metabolism; number; bhlhe40; expression ... See more keywords
LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14381
Abstract: Long noncoding RNAs (lncRNAs) have been investigated as novel regulatory molecules involved in diverse biological processes. Our previous study demonstrated that lncRNA-ES3 is associated with the high glucose-induced calcification/senescence of human aortic vascular smooth muscle… read more here.
Keywords: calcification senescence; bhlhe40; calcification; lncrna es3 ... See more keywords
BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-21-0129
Abstract: The authors show that tumor-specific T cells upregulate and require the transcriptional regulator BHLHE40 for tumor microenvironment remodeling and effective immune checkpoint therapy. BHLHE40 is a potential biomarker for immune checkpoint therapy efficacy and possible… read more here.
Keywords: bhlhe40; tumor; checkpoint therapy; immune checkpoint ... See more keywords
Mutual suppression between BHLHE40/BHLHE41 and the MIR301B-MIR130B cluster is involved in epithelial-to-mesenchymal transition of endometrial cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.27061
Abstract: BHLHE40 and BHLHE41 (BHLHE40/41) are basic helix-loop-helix type transcription factors involved in multiple cell activities including epithelial-to-mesenchymal transition (EMT). However, the expression mechanism of BHLHE40/41 in EMT remains unclear. In the present study, we showed… read more here.
Keywords: mir301b mir130b; family; expression; mir130b cluster ... See more keywords
Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1122238
Abstract: BHLHE40 is a transcription factor, whose role in colorectal cancer has remained elusive. We demonstrate that the BHLHE40 gene is upregulated in colorectal tumors. Transcription of BHLHE40 was jointly stimulated by the DNA-binding ETV1 protein… read more here.
Keywords: bhlhe40; transcription; colorectal cancer; transcription factor ... See more keywords