SUN-116 The Restored Activity of Betaine-Homocysteine S-Methyltransferase (BHMT) in Hepatocytes Reduces the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.2443
Abstract: Abstract I. Hawro: None. M. Sierra-Cruz: None. S.M. Lee: None. J. Cordoba-Chacon: None. Metabolic dysfunction-associated liver disease (MASLD) is the leading cause of chronic liver disease and has an alarming prevalence in patients with obesity… read more here.
Keywords: mice; bhmt; progression; mash ... See more keywords
The BHMT-betaine methylation pathway epigenetically modulates oligodendrocyte maturation
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DOI: 10.1371/journal.pone.0250486
Abstract: Research into the epigenome is of growing importance as a loss of epigenetic control has been implicated in the development of neurodegenerative diseases. Previous studies have implicated aberrant DNA and histone methylation in multiple sclerosis… read more here.
Keywords: betaine methylation; bhmt; betaine; bhmt betaine ... See more keywords
Exploring effects of betaine-homocysteine methyltransferase (BHMT) gene polymorphisms on fatty acid traits and cholesterol in sheep
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Indonesian Tropical Animal Agriculture"
DOI: 10.14710/jitaa.44.3.243-251
Abstract: This study was aimed to explore the effects of Betaine-Homocysteine Methyltransferase (BHMT) gene polymorphisms on fatty acid traits and cholesterol in lambs. This study used a total of 147 blood samples for genotyping including 19… read more here.
Keywords: acid traits; bhmt; fatty acid; bhmt gene ... See more keywords
2155-LB: Hepatic BHMT Integrates GIP/GLP-1 Signaling to Ameliorate Metabolic Dysfunction through Coordinated Regulation of Lipid Metabolism and Fibrogenesis
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DOI: 10.2337/db25-2155-lb
Abstract: Introduction and Objective: Metabolic dysfunction-associated steatohepatitis (MASH), a critical stage in NAFLD progression, lacks effective treatments. While GIP/GLP-1R dual agonists (GIP/GLP-1RA) show therapeutic potential, their mechanisms remain unclear. Our preclinical study identified serum BHMT downregulation… read more here.
Keywords: bhmt; glp 1ra; gip glp; hepatic bhmt ... See more keywords
Vegetable Oil-Peroxidation Product ‘Hydroxynonenal’ Causes Hepatocyte Injury and Steatosis via Hsp70.1 and BHMT Disorders in the Monkey Liver
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DOI: 10.3390/nu15081904
Abstract: Hsp70.1 has a dual function as a chaperone protein and lysosomal stabilizer. In 2009, we reported that calpain-mediated cleavage of carbonylated Hsp70.1 causes neuronal death by inducing lysosomal rupture in the hippocampal CA1 neurons of… read more here.
Keywords: bhmt; steatosis; microscopy; hsp70 bhmt ... See more keywords
Genetic and epigenetic regulation of BHMT is associated with folate therapy efficacy in hyperhomocysteinaemia.
Sign Up to like & getrecommendations! Published in 2019 at "Asia Pacific journal of clinical nutrition"
DOI: 10.6133/apjcn.201912_28(4).0025
Abstract: BACKGROUND AND OBJECTIVES Hyperhomocysteinaemia (HHcy) is an independent risk factors for several disorders, including cardiovascular disease. The understanding of the relationship among genetic, epigenetic and the efficacy of folate therapy for HHcy remain unclear. This… read more here.
Keywords: methylation; bhmt; folate therapy; efficacy ... See more keywords