Trigonostemons G and H, dinorditerpenoid dimers with axially chiral biaryl linkage from Trigonostemon chinensis.
Sign Up to like & getrecommendations! Published in 2020 at "Chirality"
DOI: 10.1002/chir.23170
Abstract: Trigonostemons G and H, two novel dimeric dinorditerpenoids, were isolated from the stem barks of Trigonostemon chinensis. Their planar structures and relative configurations were established by extensive analysis of spectroscopic data. Trigonostemons G and H… read more here.
Keywords: biaryl; chiral biaryl; biaryl linkage; trigonostemon chinensis ... See more keywords
The Stereoselective Total Synthesis of Axially Chiral Naphthylisoquinoline Alkaloids.
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DOI: 10.1021/acs.accounts.2c00432
Abstract: ConspectusThe naphthylisoquinoline (NIQ) alkaloids are a thrilling class of natural biaryls─structurally, biosynthetically, and pharmacologically. A common feature of these metabolites is the biaryl bond between their naphthalene and isoquinoline moieties, which in most cases is… read more here.
Keywords: asymmetric induction; biaryl; synthesis; total synthesis ... See more keywords
Organocatalytic Asymmetric Arylation of p-Quinone Phosphonates: A Green Access to Biaryl Monophosphorus Ligands.
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DOI: 10.1021/acs.orglett.1c02852
Abstract: Herein, we report a highly efficient organocatalytic asymmetric synthesis of axially chiral biaryl phosphonates with p-quinone phosphonates and 2-naphthols via CPA-catalyzed asymmetric arylations. A series of chiral biaryl monophosphonates were obtained in excellent yields and… read more here.
Keywords: chiral biaryl; biaryl; organocatalytic asymmetric; biaryl monophosphorus ... See more keywords
Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00149
Abstract: A series of biaryl chromans exhibiting potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM) were discovered as potential therapeutics for the treatment of type II diabetes. Optimization… read more here.
Keywords: biaryl; relationship novel; novel selective; activity relationship ... See more keywords
Chiral Selenide/Achiral Sulfonic Acid Cocatalyzed Atroposelective Sulfenylation of Biaryl Phenols via a Desymmetrization/Kinetic Resolution Sequence.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c09635
Abstract: Enantioselective synthesis of axially chiral sulfur-containing biaryl derivatives through the electrophilic sulfenylation of biaryl phenols has been achieved for the first time. This catalytic asymmetric system, which involves sequential desymmetrization and kinetic resolution, is enabled… read more here.
Keywords: achiral sulfonic; biaryl; desymmetrization kinetic; sulfenylation biaryl ... See more keywords
Organocatalytic asymmetric N-sulfonyl amide C-N bond activation to access axially chiral biaryl amino acids
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DOI: 10.1038/s41467-020-14799-8
Abstract: Amides are among the most fundamental functional groups and essential structural units, widely used in chemistry, biochemistry and material science. Amide synthesis and transformations is a topic of continuous interest in organic chemistry. However, direct… read more here.
Keywords: biaryl; chiral biaryl; amino acids; axially chiral ... See more keywords
Biaryl and atropisomeric biaryl aldehyde synthesis by one-step, metal-free benzannulation of aryl enals and propiolates
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DOI: 10.1039/d0gc02806a
Abstract: A new method involving the benzannulation of aromatic enals and two alkyl propiolate molecules has been developed as a powerful route to biaryl aldehydes simply via the promotion of dimethyl amine. The benzannulation process in… read more here.
Keywords: synthesis; biaryl; benzannulation; biaryl atropisomeric ... See more keywords
Electrochemical Organic Synthesis of Electron-Rich Biaryl Scaffolds: An Update
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DOI: 10.3390/molecules26226968
Abstract: Biaryl scaffolds are widely spread in biologically important natural products, in numerous therapeutic agents, but they are also considered a privileged class of ligands and (organo)catalysts; therefore, the development of efficient alternative methodologies to prepare… read more here.
Keywords: biaryl; electron rich; electrochemical organic; organic synthesis ... See more keywords
Genome-Guided Discovery of the First Myxobacterial Biarylitide Myxarylin Reveals Distinct C–N Biaryl Crosslinking in RiPP Biosynthesis
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DOI: 10.3390/molecules26247483
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a structurally diverse group of natural products. They feature a wide range of intriguing post-translational modifications, as exemplified by the biarylitides. These are a family of cyclic… read more here.
Keywords: guided discovery; myxarylin; biarylitide; biaryl ... See more keywords