Steric‐Adaptive Biocatalysis: Imine Reductase‐Mediated Dynamic Kinetic Resolution for Atroposelective Synthesis of Hindered Biaryl Amines
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DOI: 10.1002/advs.202510455
Abstract: As an efficient and environmentally benign strategy, enzymatic catalysis has emerged with high reactivity and selectivity for atropisomeric structures. Atropisomeric biaryl amines are of great importance in drug development and asymmetric catalysis. However, substrates with… read more here.
Keywords: imine reductase; dynamic kinetic; biaryl amines; atropisomeric biaryl ... See more keywords
Assembly of Biaryl Amines via Mild Copper-Catalyzed Coupling of Anilines with (Hetero)aryl Chlorides/Bromides.
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DOI: 10.1021/acs.orglett.5c00004
Abstract: CuI/6-hydroxy picolinohydrazide-catalyzed coupling of (hetero)aryl chlorides with anilines proceeded well at 100 °C to afford biaryl amines in a diverse manner, which represents the first example of Cu-catalyzed biaryl amines under milder conditions. The same… read more here.
Keywords: biaryl amines; catalyzed coupling; aryl chlorides; hetero aryl ... See more keywords