Synthesis and evaluation of biarylquinoline derivatives as novel HIF-1α inhibitors.
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DOI: 10.1016/j.bioorg.2022.105681
Abstract: Hypoxia-inducible factor (HIF)-1α is a key transcription factor that contributes to aggressive and drug-resistant phenotypes in tumor cells under hypoxic conditions. Therefore, targeting HIF-1α represents a promising therapeutic strategy for cancer drug development. In the… read more here.
Keywords: hif inhibitors; biarylquinoline derivatives; synthesis evaluation; novel hif ... See more keywords