Discovery of G Protein-Biased Ligands against 5-HT7R.
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DOI: 10.1021/acs.jmedchem.1c00110
Abstract: There has been significant attention concerning the biased agonism of G protein-coupled receptors (GPCRs), and it has resulted in various pharmacological benefits. 5-HT7R belongs to a GPCR, and it is a promising pharmaceutical target for… read more here.
Keywords: protein; biased ligands; ligands ht7r; discovery protein ... See more keywords
A Surprising Recipe for Designing Biased Ligands.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00764
Abstract: The determination of the potential value of receptor trafficking at melanocortin receptors has been hampered by the absence of known biased ligands. Heterobivalent MC4R ligands linking agonist to antagonist small peptidic moieties were designed and… read more here.
Keywords: recipe designing; biased ligands; surprising recipe; chemistry ... See more keywords