In a Rat Model of Opioid Maintenance, the G Protein–Biased Mu Opioid Receptor Agonist TRV130 Decreases Relapse to Oxycodone Seeking and Taking and Prevents Oxycodone-Induced Brain Hypoxia
Sign Up to like & getrecommendations! Published in 2020 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2020.02.014
Abstract: BACKGROUND Maintenance treatment with opioid agonists (buprenorphine, methadone) is effective for opioid addiction but does not eliminate opioid use in all patients. We modeled maintenance treatment in rats that self-administered the prescription opioid oxycodone. The… read more here.
Keywords: oxycodone seeking; protein biased; maintenance; biased opioid ... See more keywords