Function-related conformational dynamics of G protein–coupled receptors revealed by NMR
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical Reviews"
DOI: 10.1007/s12551-019-00539-w
Abstract: G protein–coupled receptors (GPCRs) function as receptors for various neurotransmitters, hormones, cytokines, and metabolites. GPCR ligands impart differing degrees of signaling in the G protein and arrestin pathways, in phenomena called biased signaling, and each… read more here.
Keywords: biased signaling; conformational dynamics; protein coupled; coupled receptors ... See more keywords
Arresting Developments in Biased Signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2020.04.003
Abstract: The ability to design 'biased' drugs that selectively activate G protein-coupled receptor (GPCR) signaling pathways beneficial in treating a disease, while limiting their side effects, is of broad significance. Lee et al. move us a… read more here.
Keywords: developments biased; biased signaling; arresting developments;
Biased signaling of Ca2+-sensing receptors in cardiac myocytes regulates GIRK channel activity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.03.022
Abstract: Ca2+-sensing receptors (CaSRs) belong to the class C of G protein-coupled receptors and are activated by extracellular Ca2+. CaSRs display biased G protein signaling by coupling to different classes of heterotrimeric G proteins depending on… read more here.
Keywords: biased signaling; ca2 sensing; sensing receptors; ca2 ... See more keywords
PD 102807 Induces M3 mAChR-dependent GRK-/arrestin-biased Signaling in Airway Smooth Muscle Cells.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0320oc
Abstract: G protein coupled receptors (GPCRs) are not only turned on or off to control canonical G protein signaling but may also be fine-tuned to promote qualitative/biased signaling. Qualitative signaling by M3 muscarinic acetylcholine receptors (mAChR)… read more here.
Keywords: cells 102807; ampk; airway smooth; biased signaling ... See more keywords
Structural Insights into CB1 Receptor Biased Signaling
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20081837
Abstract: The endocannabinoid system has emerged as a promising target for the treatment of numerous diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Thus far, two cannabinoid receptors, CB1 and CB2, have been discovered, which are… read more here.
Keywords: biased signaling; cb1 receptor; structural insights; receptor biased ... See more keywords
CB1 Cannabinoid Receptor Signaling and Biased Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26175413
Abstract: The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration. Despite the wide… read more here.
Keywords: cannabinoid receptor; biased signaling; cb1 cannabinoid; cb1 ... See more keywords