The potential for biased signalling in the P2Y receptor family of GPCRs.
Sign Up to like & getrecommendations! Published in 2025 at "British journal of pharmacology"
DOI: 10.1111/bph.70213
Abstract: The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled-receptor (GPCR) superfamily (P1 and P2Y) and ligand-gated ion channels (P2X). The P2Y receptors are widely expressed in… read more here.
Keywords: receptor family; p2y receptors; biased signalling; receptor ... See more keywords
MC4R biased signalling and the conformational basis of biological function selections
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17441
Abstract: The MC4R, a GPCR, has long been a major target for obesity treatment. As the most well‐studied melanocortin receptor subtype, the evolutionary knowledge pushes the drug development and structure–activity relationship (SAR) moving forward. The past… read more here.
Keywords: basis biological; mc4r biased; biased signalling; conformational basis ... See more keywords