In vitro effects of sodium bicarbonate buffer on rumen fermentation, levels of lipopolysaccharide and biogenic amine, and composition of rumen microbiota.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.7861
Abstract: BACKGROUND Diets containing high levels of carbohydrates provoke a rapid decrease of rumen pH and high levels of biogenic amines and lipopolysaccharides (LPS), which severely impair the health and performance of ruminants. The goal of… read more here.
Keywords: bicarbonate buffer; rumen fermentation; effects sodium; buffer rumen ... See more keywords
Solubility vs Dissolution in Physiological Bicarbonate Buffer
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceutical Research"
DOI: 10.1007/s11095-024-03702-5
Abstract: Phosphate buffer is often used as a replacement for the physiological bicarbonate buffer in pharmaceutical dissolution testing, although there are some discrepancies in their properties making it complicated to extrapolate dissolution results in phosphate to… read more here.
Keywords: bicarbonate; bicarbonate buffer; solubility dissolution; dissolution ... See more keywords
Simple bicarbonate buffer system for dissolution testing: Floating lid method and its application to colonic drug delivery system
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102447
Abstract: Abstract In this study, we developed a simple and easy method to use bicarbonate buffer solutions for dissolution tests. A floating lid was newly introduced to prevent the evaporation of CO2 from bicarbonate buffer solutions… read more here.
Keywords: system; floating lid; method; bicarbonate buffer ... See more keywords
Improved prediction of in vivo supersaturation and precipitation of poorly soluble weakly basic drugs using a biorelevant bicarbonate buffer in a GI transfer model.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00534
Abstract: The characterization of intestinal dissolution of poorly soluble drugs represents a key task during development of both new drug candidates and drug products. The bicarbonate buffer is considered as the most biorelevant buffer for simulating… read more here.
Keywords: transfer model; model; bicarbonate buffer; precipitation ... See more keywords