Bicaudal D2 is a novel autoantibody target in systemic sclerosis that shares a key epitope with CENP-A but has a distinct clinical phenotype.
Sign Up to like & getrecommendations! Published in 2018 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2018.01.006
Abstract: We studied the clinical correlations and epitopes of autoantibodies directed to a novel autoantigen, Bicaudal D (BICD2), in systemic sclerosis (SSc) and reviewed its relationship to centromere protein A (CENP-A). 451 SSc sera were tested… read more here.
Keywords: autoantibody; ssc; systemic sclerosis; anti bicd2 ... See more keywords
Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-019-0827-y
Abstract: For the proper organization of the six-layered mammalian neocortex it is required that neurons migrate radially from their place of birth towards their designated destination. The molecular machinery underlying this neuronal migration is still poorly… read more here.
Keywords: migration; upper layer; radial migration; cortical neurons ... See more keywords
Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010642
Abstract: Bicaudal D2 (BICD2) is responsible for recruiting cytoplasmic dynein to diverse forms of subcellular cargo for their intracellular transport. Mutations in the human BICD2 gene have been found to cause an autosomal dominant form of… read more here.
Keywords: bicd2; nesprin ranbp2; brain; brain developmental ... See more keywords