Bridged bicyclic peptides: Structure and function
Sign Up to like & getrecommendations! Published in 2018 at "Peptide Science"
DOI: 10.1002/pep2.24057
Abstract: Bicyclic peptides are conformationally rigid molecules that can bind with high affinity and specificity to their protein target, yet are significantly more protease stable than their linear or monocyclic counterparts. This emerging class of peptides… read more here.
Keywords: bridged bicyclic; peptides structure; structure function; bicyclic peptides ... See more keywords
Ribosomal Synthesis of Thioether-Bridged Bicyclic Peptides.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6451-2_5
Abstract: Many biologically active peptides found in nature exhibit a bicyclic structure wherein a head-to-tail cyclic backbone is further constrained by an intramolecular linkage connecting two side chains of the peptide. Accordingly, methods to access macrocyclic… read more here.
Keywords: bridged bicyclic; ribosomal synthesis; thioether bridged; synthesis thioether ... See more keywords
Bicyclic peptides: types, synthesis and applications.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.05.008
Abstract: Bicyclic peptides form one of the most promising platforms for drug development owing to their biocompatibility, similarity and chemical diversity to proteins, and they are considered as a possible practical tool in various therapeutic and… read more here.
Keywords: synthesis applications; applications bicyclic; bicyclic peptides; types synthesis ... See more keywords
The Symmetric Tetravalent Sulfhydryl-Specific Linker NATBA Facilitates a Combinatorial “Tool Kit” Strategy for Phage Display-Based Selection of Functionalized Bicyclic Peptides
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b01814
Abstract: The rigid conformation of constrained bicyclic peptides provides a number of advantages over larger protein-based ligands, including better chemical stability, enhanced tissue penetration, and a wider field of possible applications. Selective chemical modification strategies are… read more here.
Keywords: tetravalent; phage; linker; bicyclic peptides ... See more keywords
Enhancing the Bioactivity of Bicyclic Peptides Targeted to Grb7-SH2 by Restoring Cell Permeability
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DOI: 10.3390/biomedicines10051145
Abstract: The development of peptide inhibitors against intracellular targets depends upon the dual challenge of achieving a high affinity and specificity for the target and maintaining cellular permeability for biological activity. Previous efforts to develop bicyclic… read more here.
Keywords: cell; bicyclic peptides; grb7 sh2; targeted grb7 ... See more keywords
Biosynthetic Strategies for Macrocyclic Peptides
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26113338
Abstract: Macrocyclic peptides are predominantly peptide structures bearing one or more rings and spanning multiple amino acid residues. Macrocyclization has become a common approach for improving the pharmacological properties and bioactivity of peptides. A variety of… read more here.
Keywords: macrocyclic peptides; non ribosomal; strategies macrocyclic; biosynthetic strategies ... See more keywords