Lewis Acid-Catalyzed Formal [2π+2σ] Cycloaddition of Bicyclobutanes with Quinoxalin-2(1H)-ones: Access to Quinoxaline-Fused Aza-Bicyclo[2.1.1]hexanes.
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DOI: 10.1021/acs.orglett.4c01775
Abstract: An efficient synthesis of quinoxaline-fused aza-bicyclo[2.1.1]hexanes bearing multiple quaternary carbon centers via the intermolecular [2π+2σ] cycloaddition of bicyclo[1.1.0]butanes and quinoxalin-2(1H)-ones, facilitated by Lewis acid catalysis, is presented. This reaction is carried out under mild conditions… read more here.
Keywords: quinoxalin ones; bicyclo; quinoxaline fused; fused aza ... See more keywords
Catalytic Intermolecular Asymmetric [2π + 2σ] Cycloadditions of Bicyclo[1.1.0]butanes: Practical Synthesis of Enantioenriched Highly Substituted Bicyclo[2.1.1]hexanes.
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DOI: 10.1021/jacs.4c10968
Abstract: The high percentage of sp3-hybridized carbons and the presence of chiral carbon centers could contribute to increased molecular complexity, enhancing the likelihood of clinical success of drug candidates. Three-dimensional (3D) bridged motifs have recently garnered… read more here.
Keywords: bicyclo; highly substituted; bicyclo butanes; intermolecular asymmetric ... See more keywords
Access to Spiro-bicyclo[2.1.1]hexanes via BF3∙Et2O-Catalyzed Formal [2π + 2σ] Cycloaddition of Bicyclo[1.1.0]butanes with Benzofuran-derived Oxa(aza)dienes
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DOI: 10.1039/d4qo00511b
Abstract: Herein, we have developed a method for the construction of spiro[benzofuran-2,2'-bicyclo[2.1.1]hexanes] via BF3·Et2O-catalyzed formal [2π + 2σ] cycloaddition of bicyclo[1.1.0]butanes with benzofuran-derived oxa(aza)dienes. This transformation allowed for facile access to... read more here.
Keywords: hexanes via; via bf3; bicyclo; bf3 et2o ... See more keywords
Cycloisomerization of 7-En-2-yn-1-ones to Bicyclo[3.1.0]hexanes Using Electrophilic Fluorination or Chlorination Agents
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DOI: 10.1039/d4qo02373k
Abstract: In contrast to the π-electrophilic transition metal-catalyzed cycloisomerization of enynes, systematic studies on the reaction of enynes by activation of carbonyl groups conjugated to alkynes are lacking. Herein, we report... read more here.
Keywords: ones bicyclo; cycloisomerization ones; electrophilic fluorination; using electrophilic ... See more keywords