Discovery and Biosynthesis of the Antibiotic Bicyclomycin in Distantly Related Bacterial Classes
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DOI: 10.1128/aem.02828-17
Abstract: ABSTRACT Bicyclomycin (BCM) is a clinically promising antibiotic that is biosynthesized by Streptomyces cinnamoneus DSM 41675. BCM is structurally characterized by a core cyclo(l-Ile-l-Leu) 2,5-diketopiperazine (DKP) that is extensively oxidized. Here, we identify the BCM… read more here.
Keywords: bcm; bicyclomycin; gene cluster; distantly related ... See more keywords
Bicyclomycin Activity against Multidrug-Resistant Gram-Negative Pathogens
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DOI: 10.1128/spectrum.03790-22
Abstract: As antimicrobial resistance continues to increase, options for effectively treating multidrug-resistant (MDR) Gram-negative infections are declining. Finding ways to enhance the lethality of old agents that have unique molecular targets is important because developing new… read more here.
Keywords: gram; bicyclomycin; activity; multidrug resistant ... See more keywords