Epilepsy and systemic autoimmune diseases: A bidirectional two‐sample Mendelian randomization study
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DOI: 10.1002/epi4.70102
Abstract: Epidemiological data indicates that individuals with epilepsy exhibit an elevated susceptibility to autoimmune disorders, and conversely, those with systemic autoimmune diseases (SAD) demonstrate a heightened predisposition to epilepsy. Although an increasing number of publications support… read more here.
Keywords: sample mendelian; bidirectional two; systemic autoimmune; autoimmune ... See more keywords
The Causality between Diabetes and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
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DOI: 10.1055/a-2040-4850
Abstract: BACKGROUND Diabetes was considered as a risk factor for venous thromboembolism (VTE), but conflicting findings have been reported from observational studies. This study aimed at investigating the causal associations of type 1 and type 2… read more here.
Keywords: two sample; sample mendelian; diabetes vte; venous thromboembolism ... See more keywords
Bidirectional two-sample Mendelian randomization reveals causal link between genetic blood metabolites and tuberculosis
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DOI: 10.1186/s13568-025-01901-w
Abstract: Tuberculosis (TB), caused by infectious agent Mycobacterium tuberculosis (Mtb) seriously poses a great threat to health. An array of metabolites generated by metabolic pathways are essential for Mtb pathophysiology. However, a specific causal relationship between… read more here.
Keywords: analysis; human metabolites; bidirectional two; mendelian randomization ... See more keywords
Polycystic ovary syndrome and 25-hydroxyvitamin D: A bidirectional two-sample Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1110341
Abstract: Background Accumulating observational studies have indicated that vitamin D deficiency (serum 25-hydroxyvitamin D (25OHD) < 50 nmol/L) is common in women with polycystic ovary syndrome (PCOS). However, the direction and causal nature remain unclear. In… read more here.
Keywords: two sample; sample mendelian; polycystic ovary; ovary syndrome ... See more keywords
The Causal Relationship Between Blood Lipids and Systemic Lupus Erythematosus Risk: A Bidirectional Two-Sample Mendelian Randomization Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.858653
Abstract: Background: Although observational studies have demonstrated that blood lipids were associated with systemic lupus erythematosus (SLE), the causality of this association remains elusive as traditional observational studies were prone to confounding and reverse causality biases.… read more here.
Keywords: sle; sle ivw; bidirectional two; blood lipids ... See more keywords
Genetically predicted associations between circulating cytokines and autoimmune diseases: a bidirectional two-sample Mendelian randomization
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1404260
Abstract: Objectives Previous studies have indicated a correlation between cytokines and autoimmune diseases. yet the causality remains uncertain. Through Mendelian Randomization (MR) analysis, we aimed to investigate the causal relationships between genetically predicted levels of 91… read more here.
Keywords: cytokines autoimmune; bidirectional two; mendelian randomization; autoimmune diseases ... See more keywords
Causal associations between both psoriasis and psoriatic arthritis and multiple autoimmune diseases: a bidirectional two-sample Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1422626
Abstract: Background Numerous observational studies have identified associations between both psoriasis (PsO) and psoriatic arthritis (PsA), and autoimmune diseases (AIDs); however, the causality of these associations remains undetermined. Methods We conducted a bidirectional two-sample Mendelian Randomization… read more here.
Keywords: psoriatic arthritis; bidirectional two; autoimmune diseases; two sample ... See more keywords
No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study
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DOI: 10.3390/genes13122270
Abstract: Based on previous observational studies, the causal association between circulating adiponectin (CA) levels and ankylosing spondylitis (AS) risk remains unclear. Therefore, this study aims to investigate whether CA levels are related to the risk of… read more here.
Keywords: circulating adiponectin; adiponectin levels; levels ankylosing; bidirectional two ... See more keywords