Bifunctional Compounds as Molecular Degraders for Integrin-Facilitated Targeted Protein Degradation.
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DOI: 10.1021/jacs.2c08367
Abstract: As effective ways to regulate protein levels, targeted protein degradation technologies have attracted great attention in recent years. Here, we established a novel integrin-facilitated lysosomal degradation (IFLD) strategy to degrade extracellular and cell membrane proteins… read more here.
Keywords: targeted protein; protein degradation; protein; degradation ... See more keywords
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds
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DOI: 10.1080/00498254.2022.2140315
Abstract: Abstract Aggregates of the protein α-synuclein are associated with pathophysiology of Parkinson’s disease and are present in Lewy Bodies found in the brains of Parkinson’s patients. We previously demonstrated that bifunctional compounds composed of caffeine… read more here.
Keywords: pet probes; phase; vitro phase; phase kinetics ... See more keywords