Discovery of Small and Bifunctional Molecules Targeting PD-L1/CD73 for Cancer Dual Immunotherapy.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c00553
Abstract: In this work, a series of bifunctional PD-L1/CD73 (cluster of differentiation 73) small-molecule inhibitors were designed and synthesized. Among them, CC-5 showed the strongest PD-L1 inhibitory effects with an IC50 of 6 nM and potent… read more here.
Keywords: cd73; discovery small; small bifunctional; bifunctional molecules ... See more keywords
Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.4c00657
Abstract: Danshensu extracted with traditional Chinese medicine Salvia miltiorrhiza has a wide range of bioactivities. Danshensu containing a catechol moiety has a moderate inhibitory effect on SARS-CoV-2 3CLpro (IC50 = 2.2 μM) by a reversible covalent… read more here.
Keywords: sars cov; anti inflammatory; chalcone derivatives; bifunctional molecules ... See more keywords
Getting bifunctional molecules into cells
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.adf4412
Abstract: Description A class of transmembrane proteins helps shuttle large drugs across the cell membrane Simultaneously optimizing biochemical potency and membrane permeability remains one of the biggest challenges in drug development. For typical drug targets, such… read more here.
Keywords: bifunctional molecules; getting bifunctional; molecules cells; membrane ... See more keywords