Haloamines as Bifunctional Reagents for Oxidative Aminohalogenation of Maleimides.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01052
Abstract: An unprecedented copper-catalyzed oxidative aminohalogenation of electron-deficient maleimides with secondary amines and NXS (X = Cl, Br, I) was developed, in which the N-X bonds generated in situ were used as difunctionalized reagents. The distinctive… read more here.
Keywords: bifunctional reagents; reagents oxidative; aminohalogenation; haloamines bifunctional ... See more keywords
Radical Alkylcyanation of 1,6-Enynes with Isonitriles as Bifunctional Reagents.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c03744
Abstract: We report a radical cyano-cyclization of 1,6-enynes with isonitriles via photochemically driven nickel catalysis, forging alkenyl nitrile-tethered γ-lactams under mild conditions. This reaction leverages the photoexcitation of in situ generated nickel (isonitrile) species to facilitate… read more here.
Keywords: bifunctional reagents; alkylcyanation enynes; enynes isonitriles; isonitriles bifunctional ... See more keywords
Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c11153
Abstract: We report piperazine-fused six-membered-cyclic disulfides as redox substrates that unlock best-in-class bioreduction probes for live cell biology, since their self-immolation after reduction is unprecedentedly rapid. We develop scalable, diastereomerically pure, six-step syntheses that access four… read more here.
Keywords: bifunctional reagents; redox biology; biology; fused cyclic ... See more keywords